Similar studies for GEO DataSets (Select 200225261) - GEO DataSets

Select item 2002252611.

Effect of knockout and overexpression of the Streptococcus pneumoniae topoisomerase I regulator StaR on gene expression.

(Submitter supplied) Strain ∆staRPZnstaR was obtained to investigate genome-wide differential gene expresion when staR gene is reppressed or overexpressed by adding Zn to the culture medium. In addition, gene expression profile alterations produced upon inhibition of gyrase with Novobiocin were studied in the absence and presence of StaR.

Organism:: Streptococcus pneumoniae

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28680
8 Samples

Download data: TXT

Series

Accession:: GSE225261

ID:: 200225261

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Select item 2002430412.

Physiologic and Transcriptomic Effects Triggered by Overexpression of Wild Type and Mutant DNA Topoisomerase I in Streptococcus pneumoniae

(Submitter supplied) We obtained the topARA mutant that encodes a TopoI enzyme that shows reduced topoisomerase activity compared to the wild type gene (topAWT) and confers resistance to the antibiotic seconeolitsine. Alterations in the gene expression profile produced after overexpression of the wild type or the RA mutant of topA gene were studied. In addition, differential gene expression produced by the DNA gyrase inhibitor novobiocin (NOV) was also studied in cultures overexpressing each of the versions of TopA.

Organism:: Streptococcus pneumoniae

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28680
16 Samples

Download data: TXT

Series

Accession:: GSE243041

ID:: 200243041

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Select item 2000777493.

An increase in negative supercoiling in bacteria reveals topology-reacting gene clusters and a homeostatic response mediated by the DNA topoisomerase I gene

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Streptococcus pneumoniae R6

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL21444 GPL18733
14 Samples

Download data: TXT, XLSX

Series

Accession:: GSE77749

ID:: 200077749

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Select item 2000777484.

An increase in negative supercoiling in bacteria reveals topology-reacting gene clusters and a homeostatic response mediated by the DNA topoisomerase I gene [RNA-Seq]

(Submitter supplied) We studied the response to increased DNA-supercoiling in Streptococcus pneumoniae by using seconeolitsine (SCN), a DNA topoisomerase I inhibitor. A homeostatic transcriptional response allowing recovering of supercoiling density was observed in cells treated with subinhibitory SCN concentrations. Supercoiling increases up to 40.7% (6 µM SCN) and 72.9% (8 µM SCN) were reverted to 8.5% and 44.1%, respectively. more...

Organism:: Streptococcus pneumoniae R6

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21444
6 Samples

Download data: XLSX

Series

Accession:: GSE77748

ID:: 200077748

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000775875.

An increase in negative supercoiling in bacteria reveals topology-reacting gene clusters and a homeostatic response mediated by the DNA topoisomerase I gene [array]

Organism:: Streptococcus pneumoniae R6

Type:: Expression profiling by array

Platform:: GPL18733
8 Samples

Download data: TXT, XLSX

Series

Accession:: GSE77587

ID:: 200077587

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Select item 2001327026.

Global gene transcription analysis in response to changes in chromosome supercoiling in Streptomyces coelicolor

(Submitter supplied) Here, we address the transcriptional response to both novobiocin-induced rapid chromosome relaxation or long-term topological imbalance, both increased and decreased supercoiling, in environmental antibiotic-producing bacteria belonging to the Streptomyces genus.