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Links from GEO DataSets

Items: 3

1.

Pneumonia-induced shedding of epithelial heparan sulfate inhibits the bactericidal activity of cathelicidin

(Submitter supplied) Interrogating Staphylococcus aureus transcriptional changes in the presence or absence of glycosaminoglycans, specifically heparin.
Organism:
Staphylococcus aureus subsp. aureus NCTC 8325
Type:
Expression profiling by high throughput sequencing
Platform:
GPL33368
12 Samples
Download data: CSV
Series
Accession:
GSE231407
ID:
200231407
2.

MRSA temporal adaptation to the healthy and influenza injured lung microenvironment

(Submitter supplied) Influenza-induced respiratory failure is substantially worsened by secondary bacterial infections such as methicillin-resistant Staphylococcus aureus (MRSA). The bidirectional interaction between the influenza-injured lung microenvironment and MRSA is poorly understood. By conditioning MRSA ex vivo in bronchoalveolar lavage (BAL) fluid collected from mice at various timepoints of influenza infection, we found that influenza-injured lung microenvironment induces MRSA to increase cytotoxin expression while decreasing metabolic pathways. more...
Organism:
Staphylococcus aureus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30817
44 Samples
Download data: CSV
Series
Accession:
GSE199708
ID:
200199708
3.

RNA-sequencing of primary and secondary bacterial pneumonia

(Submitter supplied) Influenza infection is substantially worsened by the onset of secondary pneumonia caused by bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). The bidirectional interaction between the influenza-injured lung microenvironment and MRSA is poorly understood. By conditioning MRSA ex vivo in bronchoalveolar lavage fluid collected from mice at various timepoints of influenza infection, we found that the influenza-injured lung microenvironment dynamically induces MRSA to increase cytotoxin expression while decreasing metabolic pathways. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
16 Samples
Download data: CSV
Series
Accession:
GSE199707
ID:
200199707
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