Similar studies for GEO DataSets (Select 200237695) - GEO DataSets

Select item 2002376951.

Rational design of a SOCS1-edited tumor infiltrating lymphocyte therapy for solid tumors using CRISPR/Cas9 screens

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Other; Expression profiling by high throughput sequencing

Platforms:: GPL18573 GPL24247 GPL19057
92 Samples

Download data: CSV, MTX, TSV

Series

Accession:: GSE237695

ID:: 200237695

PubMed Full text in PMC Similar studies

Select item 2002376942.

Rational design of a SOCS1-edited tumor infiltrating lymphocyte therapy for solid tumors using CRISPR/Cas9 screens [TIL5746_human_invitro]

(Submitter supplied) Tumor Infiltrating Lymphocyte (TIL) therapy have shown promise in the treatment of patients with refractory solid tumors, with improvement in response rates and durability of responses nevertheless sought. To identify targets capable of enhancing the anti-tumor activity of T cell therapies, large-scale in vitro and in vivo CRISPR/Cas9 screens were performed, with the suppressor of cytokine signaling 1 (SOCS1) gene identified as a top T cell-enhancing target. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL18573
2 Samples

Download data: XLSX

Series

Accession:: GSE237694

ID:: 200237694

PubMed Full text in PMC Similar studies

Select item 2002376913.

Rational design of a SOCS1-edited tumor infiltrating lymphocyte therapy for solid tumors using CRISPR/Cas9 screens [IVP59_mc38gp100]

(Submitter supplied) Tumor Infiltrating Lymphocyte (TIL) therapy have shown promise in the treatment of patients with refractory solid tumors, with improvement in response rates and durability of responses nevertheless sought. To identify targets capable of enhancing the anti-tumor activity of T cell therapies, large-scale in vitro and in vivo CRISPR/Cas9 screens were performed, with the suppressor of cytokine signaling 1 (SOCS1) gene identified as a top T cell-enhancing target. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL19057
46 Samples

Download data: XLSX

Series

Accession:: GSE237691

ID:: 200237691

PubMed Full text in PMC Similar studies

Select item 2002376854.

Rational design of a SOCS1-edited tumor infiltrating lymphocyte therapy for solid tumors using CRISPR/Cas9 screens [IVP27_B16Ova]

(Submitter supplied) Tumor Infiltrating Lymphocyte (TIL) therapy have shown promise in the treatment of patients with refractory solid tumors, with improvement in response rates and durability of responses nevertheless sought. To identify targets capable of enhancing the anti-tumor activity of T cell therapies, large-scale in vitro and in vivo CRISPR/Cas9 screens were performed, with the suppressor of cytokine signaling 1 (SOCS1) gene identified as a top T cell-enhancing target. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL19057
34 Samples

Download data: XLSX

Series

Accession:: GSE237685

ID:: 200237685

PubMed Full text in PMC Similar studies

Select item 2002375695.

Rational design of a SOCS1-edited tumor infiltrating lymphocyte therapy for solid tumors using CRISPR/Cas9 screens [scRNA-seq]

(Submitter supplied) Tumor Infiltrating Lymphocyte (TIL) therapy have shown promise in the treatment of patients with refractory solid tumors, with improvement in response rates and durability of responses nevertheless sought. To identify targets capable of enhancing the anti-tumor activity of T cell therapies, large-scale in vitro and in vivo CRISPR/Cas9 screens were performed, with the suppressor of cytokine signaling 1 (SOCS1) gene identified as a top T cell-enhancing target. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
10 Samples

Download data: CSV, MTX, TSV

Series

Accession:: GSE237569

ID:: 200237569

PubMed Full text in PMC Similar studies

Select item 2001370166.

CRISPR screening reveals targets to reprogram long-lived effector CD8+ T cells for cancer therapy [microarray]

(Submitter supplied) CD8+ T cells can be reprogrammed for better persistence and robust effector function in TME. By performing an in vivo pooled CRISPR-Cas9 mutagenesis screening of metabolism-associated factors, we identify Regnase-1 as a major negative regulator of antitumor responses, whose deficiency results in drastically increased CD8+ T cell accumulation in tumors We used microarrays to compare the global transcription profiles of Regnase1-null, Ptpn2/Regnase1-null and Socs1/Regnase1-null tumor infiltrating CD8+ T cell populations

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL23038
6 Samples

Download data: CEL

Series

Accession:: GSE137016

ID:: 200137016

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001370157.

CRISPR screening reveals targets to reprogram long-lived effector CD8+ T cells for cancer therapy [scRNA-seq]

(Submitter supplied) CD8+ T cells can be reprogrammed for better persistence and robust effector function in TME. By performing an in vivo pooled CRISPR-Cas9 mutagenesis screening of metabolism-associated factors, we identify Regnase-1 as a major negative regulator of antitumor responses, whose deficiency results in drastically increased CD8+ T cell accumulation in tumors

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
4 Samples

Download data: TAR

Series

Accession:: GSE137015

ID:: 200137015

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001370148.

CRISPR screening reveals targets to reprogram long-lived effector CD8+ T cells for cancer therapy [ATAC-seq]

(Submitter supplied) CD8+ T cells can be reprogrammed for better persistence and robust effector function in TME. By performing an in vivo pooled CRISPR-Cas9 mutagenesis screening of metabolism-associated factors, we identify Regnase-1 as a major negative regulator of antitumor responses, whose deficiency results in drastically increased CD8+ T cell accumulation in tumors

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21103
14 Samples

Download data: TXT

Series

Accession:: GSE137014

ID:: 200137014

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001260729.

CRISPR screening reveals targets to reprogram long-lived effector CD8+ T cells for cancer therapy.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL23038 GPL21103
50 Samples

Download data: BW, CEL, TAR, TXT

Series

Accession:: GSE126072

ID:: 200126072

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012607110.

CRISPR screening reveals targets to reprogram long-lived effector CD8+ T cells for cancer therapy. [RNA-Seq]

(Submitter supplied) CD8+ T cells can be reprogrammed for better persistence and robust effector function in TME. By performing an in vivo pooled CRISPR-Cas9 mutagenesis screening of metabolism-associated factors, we identify Regnase-1 as a major negative regulator of antitumor responses, whose deficiency results in drastically increased CD8+ T cell accumulation in tumors

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
18 Samples

Download data: TXT

Series

Accession:: GSE126071

ID:: 200126071

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20012607011.

CRISPR screening reveals targets to reprogram long-lived effector CD8+ T cells for cancer therapy. [ATAC-Seq]

(Submitter supplied) CD8+ T cells can be reprogrammed for better persistence and robust effector function in TME. By performing an in vivo pooled CRISPR-Cas9 mutagenesis screening of metabolism-associated factors, we identify Regnase-1 as a major negative regulator of antitumor responses, whose deficiency results in drastically increased CD8+ T cell accumulation in tumors

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21103
8 Samples

Download data: BW

Series

Accession:: GSE126070

ID:: 200126070

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013296012.

Systematic identification of immunotherapy targets using genome-scale in vivo CRISPR screens in CD8+ cytotoxic T cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL21103 GPL13112
10 Samples

Download data

Series

Accession:: GSE132960

ID:: 200132960

PubMed Full text in PMC Similar studies

Select item 20013295913.

Systematic identification of immunotherapy targets using genome-scale in vivo CRISPR screens in CD8+ cytotoxic T cells [scRNA-Seq]

(Submitter supplied) CD8+ cytotoxic T cells play essential roles in anti-tumor immune responses. Here, we performed in vivo screens in CD8+ T cells and identified regulators of tumor infiltration and killing, which are directly relevant to cancer immunotherapy. Unlike in vitro screens, the in vivo screen robustly re-identified canonical immunotherapy targets such as PD-1 and Tim-3, along with genes that have not been characterized in T cells. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
2 Samples

Download data: TXT

Series

Accession:: GSE132959

ID:: 200132959

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013292614.

Systematic identification of immunotherapy targets using genome-scale in vivo CRISPR screens in CD8+ cytotoxic T cells [RNA-Seq]

(Submitter supplied) CD8+ cytotoxic T cells play essential roles in anti-tumor immune responses. Here, we performed in vivo screens in CD8+ T cells and identified regulators of tumor infiltration and killing, which are directly relevant to cancer immunotherapy. Unlike in vitro screens, the in vivo screen robustly re-identified canonical immunotherapy targets such as PD-1 and Tim-3, along with genes that have not been characterized in T cells. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
8 Samples

Download data: TXT

Series

Accession:: GSE132926

ID:: 200132926

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016965915.

Response of unmodified and TGFBR2 knockout tumor infiltrating lymphocytes (TIL) to TGF-B stimulation

(Submitter supplied) TGFBR2 was deleted in ovarian cancer TIL via CRISPR/Cas9 gene editing. Response of unmodified and TGFBR2 knockout TIL to TGF-B stimulation was evaluated via RNA sequencing.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
18 Samples

Download data: XLSX

Series

Accession:: GSE169659

ID:: 200169659

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20016680716.

Investigation of the transcriptional profile of stimulated HUMAN CRISPR/Cas9 MOCK and A2ARKO α-lewisY CAR T cells in the presence/absence of NECA

(Submitter supplied) Investigation of the transcriptional profile of sorted and stimulated CD8 and CD4 murine CRISPR/Cas9 MOCK and A2ARKO α-her2 CAR T cells in the presence/absence of NECA

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
24 Samples

Download data: TXT

Series

Accession:: GSE166807

ID:: 200166807

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015619217.

CRISPR/Cas9 mediated deletion of the adenosine A2AR enhances CAR T cell efficacy

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL18573 GPL19057
60 Samples

Download data

Series

Accession:: GSE156192

ID:: 200156192

PubMed Full text in PMC Similar studies

Select item 20015619118.

CRISPR/Cas9 mediated deletion of the adenosine A2AR enhances CAR T cell efficacy [murine_CRISPR_A2AKO_RNA-seq]

(Submitter supplied) Investigation of the transcriptional profile of stimulated murine CRISPR/Cas9 MOCK and A2ARKO α-HER2 CAR T cells in the presence/absence of NECA

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
12 Samples

Download data: TXT

Series

Accession:: GSE156191

ID:: 200156191

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015619019.

CRISPR/Cas9 mediated deletion of the adenosine A2AR enhances CAR T cell efficacy [human_CRISPR_A2AKO_RNA-seq]

(Submitter supplied) Investigation of the transcriptional profile of stimulated HUMAN CRISPR/Cas9 MOCK and A2ARKO α-lewisY CAR T cells in the presence/absence of NECA

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
12 Samples

Download data: TXT

Series

Accession:: GSE156190

ID:: 200156190

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20015618920.

CRISPR/Cas9 mediated deletion of the adenosine A2AR enhances CAR T cell efficacy [NECA_RNA-seq]

(Submitter supplied) Investigation of the transcriptional profile of stimulated murine α-HER2 CAR T cells in the presence/absence of NECA and/or SCH58261

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
12 Samples

Download data: TXT

Series

Accession:: GSE156189

ID:: 200156189

PubMed Full text in PMC Similar studies SRA Run Selector

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