GEO DataSets

(Submitter supplied) DSP RNA profling using the whole transcriptome atlas kit was performed on a cohort of head and neck cancer tumour samples from patients who received immunotherapy.

Organism:

Homo sapiens

Type:

Other

Platform:

GPL34199

38 Samples

Download data: CSV

(Submitter supplied) DSP protein profiling using the nanostring immuno-oncology kit was performed on head and neck tumor tissue samples De proteins were identified in tumour and stromal compartments

Organism:

Homo sapiens

Type:

Other

Platform:

GPL34246

375 Samples

Download data: CSV

(Submitter supplied) DSP RNA profling using the whole transcriptome atlas kit was performed on a tissue sample perior to immunotherapy from a patient with head and neck cancer.

Organism:

Homo sapiens

Type:

Other

Platform:

GPL24676

9 Samples

Download data: CSV, PKC

(Submitter supplied) Nanostring DSP was performed on 187 ROIS from 17 HNSCC patients and differential analysis was performed by patient response groups to immunotherapy. DE proteins were identified in both tumour and stromal tissue compartments

Organism:

Homo sapiens

Type:

Other

Platform:

GPL29263

187 Samples

Download data: CSV

(Submitter supplied) Head and neck squamous cell carcinoma (HNSCC) often present with locoregional or distant disease, despite multimodal therapeutic approaches, which include surgical resection, chemoradiotherapy, and more recently immunotherapy for metastatic, or recurrent HNSCC. Therapies often target the primary and nodal regional HNSCC sites, and efficacy at controlling occult distant sites remains poor. Whilst our understanding of the tumour microenvironment, conducive for effective therapies is increasing, the biology underpinning locoregional sites remains unclear. more...

Organism:

Homo sapiens

Type:

Other

Platform:

GPL29263

136 Samples

Download data: CSV

(Submitter supplied) Purpose: Cancer drug development is currently limited by a paradigm of preclinical evaluation that does not adequately recapitulate the complexity of the intact human tumor microenvironment (TME). To overcome this, we combined trackable intratumor microdosing (CIVOTM) with spatial biology readouts to directly assess drug effects in patient tumors in situ. Patients and Methods: In a first-of-its-kind Phase 0 clinical trial, we explored the effects of an investigational stage SUMOylation Activating Enzyme (SAE) inhibitor, subasumstat (TAK-981) in 12 patients with head and neck carcinoma (HNC). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL32550

354 Samples

Download data: TXT

(Submitter supplied) An in-depth investigation of the pancreatic ductal adenocarcinoma tumour microenvironment highlights PD-1 and TIGIT, or their corresponding ligands, as potential targets for combinatorial monoclonal antibody therapy to treat this devastating disease. 

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

3 Samples

Download data: CSV

(Submitter supplied) As cancer immunotherapy and precision medicine dynamically evolve, there is greater need for pre-clinical models that can better replicate the intact tumor and its complex tumor microenvironment (TME). Precision-cut tumor slices (PCTS) have recently emerged as an ex vivo human tumor model, offering the opportunity to study individual patient responses to targeted therapies, including immunotherapies. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21697

26 Samples

Download data: XLSX

(Submitter supplied) Novel immunotherapy combination therapies have improved outcomes for patients with hepatocellular carcinoma (HCC), but responses are limited to a subset of patients. Little is known about the inter- and intra-tumor heterogeneity in cellular signaling networks within the HCC tumor microenvironment (TME) that underlie responses to modern systemic therapy. We applied spatial transcriptomics (ST) profiling to characterize the tumor microenvironment in HCC resection specimens from a prospective clinical trial of neoadjuvant cabozantinib, a multi-tyrosine kinase inhibitor that primarily blocks VEGF, and nivolumab, a PD-1 inhibitor in which 5 out of 15 patients were found to have a pathologic response at the time of resection. more...

Organism:

Homo sapiens

Type:

Other

Platform:

GPL24676

7 Samples

Download data: TAR

(Submitter supplied) We analyzed 40,799 single cells from nine samples and found that in EGFR-mutant LUAD, tumor cells generated an immunosuppressive microenvironment by releasing cytokines to attract suppressive immune cells such as myeloid-derived suppressor cells (MDSCs) directly or indirectly by interacting with macrophages, dendritic cells, or other cell types. By contrast, EGFR wild-type LUAD had a greater ability to recruit immunocompetent T cells such as TRMs and Th1 cells, thus driving a proinflammatory microenvironment.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24676

9 Samples

Download data: TSV, TXT