Similar studies for GEO DataSets (Select 2051) - GEO DataSets

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Items: 16

Select item 20511.

Peritoneal mesotheliomas induced by o-nitrotoluene and bromochloracetic acid: dose response

Analysis of peritoneal mesotheliomas induced by various concentrations of o-nitrotoluene (o-NT) or bromochloracetic acid (BCA). o-NT is a high production chemical. BCA is a by-product of drinking water disinfection. Results provide insight into the mechanisms underlying mesothelioma formation.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, log10 ratio, 2 agent, 5 dose sets

Platform:: GPL890
Series:: GSE4682
16 Samples

Download data: TIFF, TXT

DataSet

Accession:: GDS2051

ID:: 2051

Select item 2000048622.

Hog1 ChIP Chip

(Submitter supplied) Yeast Hog1-3HA ChIP-Chip in triplicate Keywords: ChIP-Chip

Organism:: Saccharomyces cerevisiae

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL1689
3 Samples

Download data

Series

Accession:: GSE4862

ID:: 200004862

Select item 2000046823.

Gene expression analysis of peritoneal mesotheliomas following chemical treatment in F344 rats

(Submitter supplied) This study was performed to characterize the gene expression profile of rat peritoneal mesothelioma (RPM) formation following treatment of Fischer 344 rats with o-nitrotoluene (o-NT) or bromochloracetic acid (BCA). Keywords: Rat, Mesotheliomas, Bromochloractetic acid, o-Nitrotoluene, Carcinogenesis, Microarray

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS2051
Platform:: GPL890
16 Samples

Download data: TIFF, TXT

Series

Accession:: GSE4682

ID:: 200004682

Select item 2000475814.

Global gene expression profiling of mesotheliomas from vehicle control and VDC-exposed male F344N rats

(Submitter supplied) A recent two-year NTP cancer bioassay showed a marked increase in the incidence of malignant mesothelioma arising from the tunica vaginalis in male Fischer 344/N rats exposed to Vinylidene chloride (VDC). Aged male F344/N rats are prone to developing spontaneous peritoneal mesotheliomas, which also arise predominantly from the tunica vaginalis of the testes. A definitive mechanism for the observed increased incidence in VDC-exposed rats is unknown. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL1355
19 Samples

Download data: CEL, CHP

Series

Accession:: GSE47581

ID:: 200047581

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000414945.

Hog1 bypasses stress-mediated down-regulation of transcription by PolII redistribution and chromatin remodeling

(Submitter supplied) Cells are subjected to dramatic changes on gene expression upon environmental changes. Stress causes a general down-regulation of gene expression together with the induction of a set of stress-responsive genes. Genome wide localisation studies showed major changes on Pol II localisation towards stress-responsive genes in contrast to housekeeping genes. Pol II relocalisation requires of the Hog1 SAPK, which also associates at stress-responsive loci. more...

Organism:: Saccharomyces cerevisiae

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13272
15 Samples

Download data: BED

Series

Accession:: GSE41494

ID:: 200041494

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000414516.

Hog1 bypasses stress-mediated downregulation of transcription by PolII redistribution and chromatin remodeling

(Submitter supplied) Hog1 bypasses stress-mediated downregulation of transcription by PolII redistribution and chromatin remodeling Keyword: genetic modification

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array

Platform:: GPL7542
3 Samples

Download data: GPR

Series

Accession:: GSE41451

ID:: 200041451

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001186557.

Role of Sko1 sumoylation in regulating target site binding

(Submitter supplied) We examine how SUMO post-translational modification of the yeast transcription factor Sko1 affects its binding site selection and affinity. Chromatin immunoprecipitation followed by next-generation sequencing was performed in strains expressing wild-type Sko1 (Sko1-WT) or Sko1 that harbors an Arg-to-Lys mutation at Lys 567 (Sko1-MT), that impairs its sumoylation. We find that, compared with Sko1-WT, SUMO-deficient Sko1 binds numerous additional sites that are near promoters of non-Sko1 target genes. more...

Organism:: Saccharomyces cerevisiae

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17342
12 Samples

Download data: TXT

Series

Accession:: GSE118655

ID:: 200118655

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000161388.

Transcriptome analysis of mesothelioma induced by intraperitoneal injections of ferric saccharate in rats

(Submitter supplied) Iron plays an important role in oxidative tissue damage and subsequent carcinogenesis. Iron deposition in the peritoneum causes neoplastic changes. Here we used gene expression microarrays to find common genetic alterations in a rat model by repeated intraperitoneal injections of ferric saccharate. Gene expression microarray revealed the expression of uromodulin (Umod) is increased in mesothelioma approximately 250-fold.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL7294
12 Samples

Download data: TXT

Series

Accession:: GSE16138

ID:: 200016138

Select item 2000021059.

whole reference dataset (cell wall chip)

(Submitter supplied) Data processing included: 1. Filtering of those bad quality image spots (these includes alterations on the shape or hybridization) 2. Filtering of low intensity which was done flagging with -50 those spots whose feature intensity was lower in any of both channels than the average of the local background in the corresponding channel for all spots. However, those genes whose feature intensity in one channel was under the limit but in the other channel was 5 times over limit were considered as on-off genes and were not filtered. more...

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array

Platforms:: GPL1433 GPL1428
20 Samples

Download data

Series

Accession:: GSE2105

ID:: 200002105

Select item 20000743610.

Profiling of genes regulated by TGF-beta in lung carcinoma (A549) and immortalized lung epithelial (HPL1D)cells.

(Submitter supplied) TGF-beta is one of the key cytokines implicated in various disease processes including cancer. TGF-beta inhibits growth and promotes apoptosis in normal epithelial cells and in contrast, acts as a pro-tumour cytokine by promoting tumour angiogenesis, immune-escape and metastasis. It is not clear if various actions of TGF-beta on normal and tumour cells are due to differential gene regulations. Hence we studied the regulation of gene expression by TGF-beta in normal and cancer cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2932
Platform:: GPL3515
12 Samples

Download data

Series

Accession:: GSE7436

ID:: 200007436

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 293211.

TGF-beta effect on normal and tumor cell lines: time course

Analysis of normal lung epithelial HPL1D cells and lung adenocarcinoma A549 cells treated with TGF-beta for up to 12 hours. TGF-beta inhibits growth and promotes apoptosis in normal epithelial cells but acts as a pro-tumor cytokine by promoting tumour angiogenesis, immune-escape, and metastasis.

Organism:: Homo sapiens

Type:: Expression profiling by array, log2 ratio, 2 cell line, 3 time sets

Platform:: GPL3515
Series:: GSE7436
12 Samples

Download data

DataSet

Accession:: GDS2932

ID:: 2932

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20001074812.

Expression data from brain tissue of Rattus norvegicus treated with D-Serine

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS3643
Platform:: GPL1355
24 Samples

Download data: CEL

Series

Accession:: GSE10748

ID:: 200010748

Select item 364313.

D-serine effect on the brain: dose response

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 agent, 6 dose sets

Platform:: GPL1355
Series:: GSE10748
24 Samples

Download data: CEL

DataSet

Accession:: GDS3643

ID:: 3643

Select item 20004243814.

PTHRP/Adenylate cyclase promotes parietal whereas Wnt/β-catenin signaling promotes visceral endoderm differentiation of rat XEN cells.

(Submitter supplied) In this study we showed that rat XEN cells grown in the presence of a GSK3 inhibitor exhibited enhanced formation of cell contacts and decreased motility. In contrast, treatment with forskolin induced the PE formation and epithelial-mesenchymal transition (EMT) in rat XEN cells. Using microarray and real-time PCR assays, we found that VE versus PE formation of rat XEN cells was correlated with change in expression levels of VE or PE marker genes. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL10741
12 Samples

Download data: CEL

Series

Accession:: GSE42438

ID:: 200042438

Select item 20001711815.

TCEAL7 Inhibition of c-Myc Activity in Alternative Lengthening of Telomeres Regulates hTERT Expression

(Submitter supplied) Replicative senescence forms a major barrier to tumor progression. Cancer cells bypass this by using one of the two known telomere maintenance mechanisms: telomerase or the recombination-based alternative lengthening of telomeres (ALT) mechanism. The molecular details of ALT are currently poorly understood. We have previously shown that telomerase is actively repressed through complex networks of kinase, gene expression, and chromatin regulation. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6480
60 Samples

Download data: TXT

Series

Accession:: GSE17118

ID:: 200017118

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004716116.

Expression data from visceral mesothelium (omentum) and parietal meosthelium

(Submitter supplied) Mesothelia, which cover all coelomic organs and body cavities in vertebrates, perform diverse functions in embryonic and adult life. Yet, mesothelia are traditionally viewed as simple, uniform epithelia. We used microarrays to demonstrate distinct differences between visceral and parietal mesothelia, the most basic subdivision of this tissue type, in terms of gene expression.