GEO DataSets

Analysis of reinnervated tibialis anterior muscles that were previously denervated for 4 weeks. Denervation-induced myofiber atrophy can be reversed by reinnervation. Results provide insight into the molecular mechanisms contributing to myofiber growth after reinnervation.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL341

Series:

GSE2566

6 Samples

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(Submitter supplied) Three male 8-week-old Wistar rats were used. The peroneal nerve of the animals was transected and sutured to the biceps femoris muscle. Four weeks later, the proximal stump was sutured to the distal stump. The animals survived for 8 weeks. All experiments were performed under Ketanest (ketamine hydrochloride, Essex Pharma GmbH, Munich, Germany; 100 mg/kg) and Rompun (xylazine hydrochloride, Bayer, Leverkusen, Germany; 10 mg/kg) anesthesia. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2243

Platform:

GPL341

6 Samples

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(Submitter supplied) The right legs of 8 Brown-Norway male rats were denervated by a high sciatic nerve section in the hip region of the hind limb.Two months after denervation (6 months of age), extensor digitorum longus (EDL) muscles were removed from the operated legs. The EDL muscles from 8 age-matched non-operated rats served as innervated controls. Total RNA was isolated, labeled cDNA was prepared and hybridized to the Rat Atlas 1.2 Array II membranes (Clontech Laboratories, Palo Alto, CA). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL154

16 Samples

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(Submitter supplied) Pbx homeodomain proteins have been implicated in the regulation of gene expression during muscle development. Whether Pbx proteins are required broadly for the regulation of muscle gene expression or are required for the expression of a specific subset of muscle gene expression is not known. We employed microarrays to determine the requirements for Pbx proteins during zebrafish development. Keywords: developmental time course analysis

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL1319

12 Samples

Download data: CEL

(Submitter supplied) Aging of skeletal muscle tissue is characterized by loss of metabolic and contractile competence. It is thought that this phenomenon is driven via extrinsic and intrinsic factors. In order to identify age-dependent changes intrinsic to the muscle cell, microarray transcriptional profiles and measurements of glucose metabolism were performed in primary cultured human myotubes at different time points over seven weeks. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS647

Platform:

GPL8300

7 Samples

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Examination of aging myotubes from a muscle biopsy incubated in glucose. Myotubes in 25 mM glucose at 2, 3, 4, 5, and 7 weeks, and in 10 mM glucose at 4 weeks examined in reference to 0 mM glucose control at 1 week.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 growth protocol, 6 time sets

Platform:

GPL8300

Series:

GSE1144

7 Samples

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(Submitter supplied) Analysis of effect of hindlimb suspension and reloading on C57Bl/6 mouse soleus muscle. Experimental groups examined: -Control mice, 14 days -Hindlimb suspension for 7 days -Hindlimb suspension for 7 days, and subsequent reloading for 1 day -Hindlimb suspension for 7 days, and subsequent reloading for 7 days Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1097

23 Samples

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(Submitter supplied) Hindlimb suspension for 7 days, subsequent reloading for 7 days Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1097

5 Samples

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(Submitter supplied) Hindlimb suspended for 7 days, subsequent reloading for 1 day Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1097

6 Samples

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(Submitter supplied) Hindlimb suspended for 7 days Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1097

6 Samples

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(Submitter supplied) Control mice, 14 days Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1097

6 Samples

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(Submitter supplied) The right legs of 3 months old CD1 mice were denervated by unilaterally cutting the sciatic nerve at the level of trochanter, resulting in a permanent denervation of the lower hindleg. At the indicated times, animals were killed by cervical dislocation and tibialis anterior (TA) muscles were dissected out and frozen in liquid nitrogen. The expression analysis was carried out at five time points, namely just after denervation (time 0) and 1, 3, 7 and 14 days after nerve interruption. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1523

10 Samples

Download data: TIFF

(Submitter supplied) 2,061 muscle-specific cDNA probes (300-600 bp), restricted to the 3'-end of each mRNA, were spotted in quadruplicates. MICROARRAY FABRICATION: The cDNA inserts were cloned in the plasmid vector pZErO-1 (Invitrogen) and amplified by PCR with universal primers (A: 5’-TCCGGCTCGTATGTTGTGTGG-3’, B: 5’-GTTGTAAAACGACGGCCAGTG-3’). The quality of each amplicon was monitored on agarose gels: cDNA probes showing more than a single size product, described by a ‘WARNING’ message, were excluded from subsequent microarray analyses. more...

Organism:

Mus musculus

1 Series

10 Samples

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(Submitter supplied) Because of its high plasticity and rapid growth rate, turkey skeletal muscle is an important model for studying mechanisms responsible for vertebrate skeletal muscle development and function. Skeletal muscle is composed of metabolically heterogeneous myofibers that exhibit high plasticity at both the morphological and transcriptional levels. The objective of this study was to employ microarray analysis to elucidate the differential gene expression between the tonic- “red” Anterior latissimus dorsi (ALD) muscle, the phasic- “white” Posterior latissimus dorsi (PLD), and “mixed”-phenotype Biceps femoris (BF) in 1-week and 19-week old male turkeys. more...

Organism:

Meleagris gallopavo

Type:

Expression profiling by array

Platform:

GPL9788

34 Samples

Download data: TXT

(Submitter supplied) The extraocular muscles (EOM) are anatomically and physiologically distinct from other skeletal muscles. EOM are preferentially affected in mitochondrial myopathies, but spared in Duchenne's muscular dystrophy. The anatomical and pathophysiological properties of EOM have been attributed to their unique molecular makeup: an allotype. We used expression profiling to define molecular features of the EOM allotype. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS254

Platform:

GPL85

16 Samples

Download data: CEL

Molecular definition of extraocular muscles (EOM). EOM are anatomically and physiologically distinct from other skeletal muscles.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 tissue sets

Platform:

GPL85

Series:

GSE471

16 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

16 Samples

Download data: IDAT

(Submitter supplied) For additional details see Bongers et al, Spermine Oxidase Maintains Basal Skeletal Muscle Gene Expression and Fiber Size, and Is Strongly Repressed by Conditions that Cause Skeletal Muscle Atrophy . Am J Physiol Endocrinol Metab. 2014 [under review]

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

8 Samples

Download data: IDAT

(Submitter supplied) For additional details see Bongers et al, Spermine Oxidase Maintains Basal Skeletal Muscle Gene Expression and Fiber Size, and Is Strongly Repressed by Conditions that Cause Skeletal Muscle Atrophy . Am J Physiol Endocrinol Metab. 2014 [under review]

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

8 Samples

Download data: IDAT

(Submitter supplied) We showed that nandrolone attenuated subacute, but not acute, denervation atrophy and upregulation of MAFbx. The present study explored the molecular determinants for this time-dependent effect using microarray analysis to identify genes that were differentially regulated by administration of nandrolone for 7 days beginning either concomitantly with denervation (7 days) or 29 days later (35 days)

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

12 Samples

Download data: CEL, TXT