GEO DataSets

Analysis of uterine fibroids with mutations in the fumarate hydratase (FH) gene. FH catalyzes the hydration of fumarate in the TCA cycle. Heterozygous germline mutations in FH cause uterine fibroids and renal cell cancer. Results provide insight into the pathogenesis of TCA cycle-related tumors.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 3 genotype/variation sets

Platform:

GPL96

Series:

GSE2725

10 Samples

Download data: CEL, EXP, RPT

(Submitter supplied) A series of gene expression measurements of normal myometrium and uterine fibroids with mutated or wild-type fumarate hydratase (FH) gene. Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2246

Platform:

GPL96

10 Samples

Download data: CEL, EXP, RPT

(Submitter supplied) A series of gene expression measurements of uterine fibroids with mutated fumarate hydratase (FH) gene and normal myometrium. Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2245

Platform:

GPL96

18 Samples

Download data: CEL, EXP, RPT

(Submitter supplied) A series of gene expression measurements of uterine fibroids with mutated or wild-type fumarate hydratase (FH) gene. Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1476

Platform:

GPL96

22 Samples

Download data: CEL, EXP, RPT

Analysis of uterine fibroids with mutations in the fumarate hydratase (FH) gene. FH catalyzes the hydration of fumarate in the TCA cycle. Heterozygous germline mutations in FH cause uterine fibroids and renal cell cancer. Results provide insight into the pathogenesis of TCA cycle-related tumors.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 2 genotype/variation, 11 individual sets

Platform:

GPL96

Series:

GSE2724

18 Samples

Download data: CEL, EXP, RPT

Analysis of 7 uterine fibroids carrying fumarate hydratase (FH) mutations. FH catalyzes hydration of fumarate in the Krebs tricarboxylic acid cycle. Results provide insight into the connection between the disruption of mitochondrial metabolic pathways and neoplasia.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL96

Series:

GSE2152

22 Samples

Download data: CEL, EXP, RPT

(Submitter supplied) Gene expression profiles of normal kidney (3 technical replicates) and a renal tumor (3 technical replicates) from a hereditary leiomyomatosis and renal cell cancer (HLRCC) patient carrying a germline mutation in the fumarate hydratase (FH) gene.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10184

6 Samples

Download data: CEL

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) This is the first use of cDNA microarrays to study the influence of GH transgenesis on liver gene expression in a non-mammalian vertebrate. Three groups of salmon were examined: transgenic on full ration (T), transgenic on restricted ration (R), and control nontransgenic (C). Daily weight gains in T were approximately 8-fold higher than in C, and 4-fold higher than in R. Differential gene expression in T, R, and C samples was determined using ~ 16,000 gene microarrays. more...

Organism:

Salmo salar; Oncorhynchus kisutch

Type:

Expression profiling by array

Platform:

GPL2989

6 Samples

Download data

(Submitter supplied) The influence of GH transgenesis on liver gene expression in coho salmon was examined. Gene expression in livers of transgenic salmon on a restricted ration (R) was compared to that in livers of nontransgenic control salmon (C). Keywords: Transcript profile

Organism:

Salmo salar

Type:

Expression profiling by array

Platform:

GPL2844

8 Samples

Download data

(Submitter supplied) Coho Salmon GH Transgenic Study Keywords: other

Organism:

Salmo salar; Oncorhynchus kisutch; Oncorhynchus mykiss

Type:

Expression profiling by array

Platform:

GPL966

9 Samples

Download data: TIFF

(Submitter supplied) We used gene microarray analysis to compare the global expression profile of genes involved in adaptation to exercise training in skeletal muscle from chronically strength/resistance trained (ST), endurance trained (ET) and untrained control subjects (Con). Resting skeletal muscle samples (~100mg) were obtained from the vastus lateralis of 20 subjects (Con n=7, ET n=7, ST n=6; trained groups >8 years specific training). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6042

21 Samples

Download data: GPR

(Submitter supplied) Uterine leiomyomata, or fibroids, are benign tumors of the uterine myometrium that significantly affect up to 30% of reproductive-age women. Despite being the primary cause of hysterectomy in the United States, accounting for up to 200,000 procedures annually, the etiology of leiomyoma remains largely unknown. Due to the lack of an effective medicinal therapy for these tumors, this disease continues to have a tremendous negative impact on women’s health. more...

Organism:

Rattus norvegicus; Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL1355 GPL570

106 Samples

Download data: CEL