GEO DataSets

Analysis of placentas of C57BL animals following antenatal steroid (AS) treatment using dexamethasone. AS therapy is used to promote fetal lung maturation. Results provide insight into the risks associated with AS therapy.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL339

Series:

GSE4165

6 Samples

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(Submitter supplied) Antenatal steroids (AS) are used to augment fetal lung maturity and there is a major concern that they impair fetal growth. If delivery is delayed after using AS, placental function and hence fetal growth may be compromised even further. We treated three pairs of pregnant C57/BL mice with AS and studied changes in placental gene expression by microarray analysis, these results were later confirmed by semi quantitative RT-PCR, in situ hybridization and Oligo ApopTaq assay. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2314

Platform:

GPL339

6 Samples

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(Submitter supplied) Protein deficiency and intestinal parasite infection during pregnancy impair fetal growth through passage of signals from the maternal environment which signal impairment of fetal growth. The placenta is an important regulator of the transfer of these signals through differential expression of key placental genes. We used microarrays to examine placental gene expression responses to maternal protein deficiency (6% vs. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL16570

12 Samples

Download data: CEL, CHP

(Submitter supplied) RNA from cultured human bronchial epithelial cells treated for 8 hours or for 24 hours with medium alone, interferon gamma, dexamethasone or both interferon gamma and dexamethasone. Keywords = interferon gamma Keywords = dexamethasone Keywords = human bronchial epithelial cells Keywords: dose response

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1256

Platform:

GPL8300

36 Samples

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Analysis of bronchial epithelial cells treated with interferon (IFN) gamma, or dexamethasone (dex), or both. IFN-gamma plays a role in lung inflammatory responses and corticosteroids such as dex are used as treatments for inflammation. Cells examined 8 or 24 hours after treatment.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 agent, 2 time sets

Platform:

GPL8300

Series:

GSE1815

36 Samples

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(Submitter supplied) Gene expression patterns of bovine placenta from initial to late stage of pregnancy were investigated by using the our custom designed utero-placental cDNA microarray. Keywords: Time course

Organism:

Bos taurus

Type:

Expression profiling by array

Platform:

GPL1221

18 Samples

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(Submitter supplied) Background: Glucocorticoids (GCs) are widely used anti-inflammatory drugs. While useful in clinical practice, patients taking GCs often suffer from skeletal side effects including growth retardation and decreased bone quality in adults. On a physiological level, GCs have been implicated in the regulation of chondrogenesis and osteoblast differentiation, as well as maintaining homeostasis in cartilage and bone. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2802

Platform:

GPL1261

12 Samples

Download data: CEL, CHP, EXP

Analysis of primary cultured fetal chondrocytes treated with pharmacological doses of dexamethasone (DEX) for 6 and 24 hours. DEX is a synthetic glucorticoid (GC) receptor agonist. Results provide insight into the effects of pharmacological GC on chondrocytes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 time sets

Platform:

GPL1261

Series:

GSE7683

12 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) It has been shown that dexamethasone (Dex) impairs the normal lung septation that occurs in the early postnatal period. Treatment with retinoic acid (ATRA) abrogates the effects of Dex. To understand the molecular basis for the Dex indiced inhibition of the formation of the alveoli and the ability of ATRA to prevent the inhibition of septation, gene expression was analyzed in 4-day old mice treated with diluent (control), Dex-treated and ATRA+Dex-treated. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS250

Platform:

GPL81

8 Samples

Download data: CEL

Analysis of how dexamethasone (DEX) inhibits normal lung septation and alveoli formation, and mechanism by which retinoic acid (ATRA) protects against DEX. Three day old mice treated with ATRA or control. On day 4, half of each group administered DEX.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 protocol sets

Platform:

GPL81

Series:

GSE484

8 Samples

Download data: CEL