GEO DataSets

Analysis of FACS-purified A2B5+ oligodendrocyte progenitors and O4+ oligodendrocytes from the brains of postnatal day 7 Sprague Dawley males. Results provide insight into the mechanisms underlying oligodendrocyte maturation.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 development stage sets

Platform:

GPL342

Series:

GSE5940

9 Samples

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(Submitter supplied) Oligodendrocytes undergo extensive changes as they differentiate from progenitors into myelinating cells. To better understand the molecular mechanisms underlying this transformation, we performed a comparative analysis using gene expression profiling of A2B5+ oligodendrocyte progenitors and O4+ oligodendrocytes. Cells were sort-purified ex vivo from postnatal rat brain using flow cytometry. Using Affymetrix microarrays, 1707 transcripts were identified with a more than twofold increase in expression inO4+oligodendrocytes. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS2379 GDS2380

Platforms:

GPL341 GPL342

18 Samples

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Analysis of FACS-purified A2B5+ oligodendrocyte progenitors and O4+ oligodendrocytes from the brains of postnatal day 7 Sprague Dawley males. Results provide insight into the mechanisms underlying oligodendrocyte maturation.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 development stage sets

Platform:

GPL341

Series:

GSE5940

9 Samples

Download data

(Submitter supplied) Like neurons, oligodendrocytes (OL) are cells with elaborate morphology that probably require asymmetrical spatial regulation of biological processes. Formation of membrane protrusions is critical for OL development and interaction with axons. We hypothesized that the enrichment of specific mRNAs in protrusions of oligodendrocyte precursor cells (OPC) is important for morphological differentiation, thus having an impact in myelination. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL14844

4 Samples

Download data: TXT

(Submitter supplied) Metformin restores myelination potential of aged rat A2B5+ oligodendroglia (OL) progenitor cells and may enhance recovery in children with post-radiation brain injury. Human late progenitor cells (O4+A2B5+) have superior capacity to ensheath nanofibers compared to mature OLs, with cells from pediatric sources exceeding adults. In this study we assessed effects of metformin on ensheathment capacity of human adult and pediatric progenitors and mature OLs and relate differences to transcriptional changes. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24676

29 Samples

Download data: XLSX