Similar studies for GEO DataSets (Select 2470) - GEO DataSets

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Items: 2

Select item 24701.

Neural tube defect: amniotic fluid

Analysis of amniotic fluid samples from pregnant women carrying fetuses with neural tube defects (NTDs) diagnosed during ultrasound examination. Results provide insight into the feasibility of using amniotic fluid samples to characterize polygenic disorders, such as NTD, at the molecular level.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state sets

Platform:: GPL570
Series:: GSE4182
9 Samples

Download data: CEL

DataSet

Accession:: GDS2470

ID:: 2470

Select item 2000041822.

Genetic background of the polygenic neural tube defect

(Submitter supplied) In polygenic disorders we do not know exactly, how many genes are involved in the pathomechanism, but the analysis of fetal gene expression can get us closer to the solution. In our study we were searching for the genetic background of the polygenic neural tube defect, which is the second most common birth defect in the world (1 in 1000 live births). Our data revealed novel candidate genes, like SLAP, LST1 and BENE, which can play an important role in the pathogenesis of neural tube defects. more...