GEO DataSets

Analysis of white blood cells (WBCs) isolated from spleens of intact and gonadectomized (gdx) males and females up to 14 days after inoculation with Plasmodium chabaudi. Results provide insight into molecular mechanisms mediating the sexual dimorphism in resistance to blood-stage malaria infection.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 disease state, 2 gender, 2 protocol, 4 time sets

Platform:

GPL339

Series:

GSE4324

48 Samples

Download data: CEL

(Submitter supplied) The goal of this study was to examine whether immune responses to Plasmodium chabaudi infection differ between the sexes and are altered by the presence of gonadal steroids. Gonadally-intact males were more likely than intact females to die following P. chabaudi infection, exhibit slower recovery from infection-associated weight loss, hypothermia, and anemia, have reduced IFNγ-associated gene expression and IFNγ production during peak parasitemia, and produce less antibody during the recovery phase of infection. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2524

Platform:

GPL339

48 Samples

Download data: CEL

(Submitter supplied) Infection of C57BL/6 mice with Plasmodium berghei ANKA (PbA) is a well-established experimental model of cerebral malaria (ECM). ECM is characterised by high levels of parasite sequestration and recruitment of pathogenic CD8+ T cells to the brain. The role of CD4+ T cells in this model has not yet been fully elucidated, although our laboratory has recently shown that CD4+ T cell depletion prior to infection results in significantly lower parasite burdens and protection from ECM. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

12 Samples

Download data: TXT

(Submitter supplied) Patients with febrile malaria were recruited in order to determine Peripheral Blood Mononuclear Cell (PBMC) gene expression during malaria. Blood was harvested from patients during the acute phase of the illness, and then patients were given a curative regimen of antimalarials. Three to four weeks after treatment, patients returned to the malaria clinic and blood was collected again, in order that each patient could serve as his or her own control. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6102

28 Samples

Download data: TXT

(Submitter supplied) Gene expression profiles were examined in whole lung tissue collected from male and female Long-Evans rats at different time points after inoculation with Seoul virus (i.e., the species-specific hantavirus that infects Norway rats) We used microarray analyses to analyze global gene expression differences between the sexes during hantavirus infection Keywords: time course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3050

Platform:

GPL341

24 Samples

Download data: CEL

Analysis of male and female lungs at various time points up to 40 days post-infection with Seoul hantavirus. Males and females differ in their susceptibility to several RNA and DNA viruses. Results provide insight into the influence of gender in the response to Seoul hantavirus infections.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 gender, 2 infection, 4 time sets

Platform:

GPL341

Series:

GSE7271

24 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

24 Samples

Download data

(Submitter supplied) Males and females exhibit profound differences in immune responses and disease susceptibility. However, the factors responsible for sex differences in tissue immunity remain poorly understood. Here, we uncover a dominant role for type 2 innate lymphoid cells (ILC2) in shaping sexual immune dimorphism within the skin. Mechanistically, negative regulation of ILC2 by androgens leads to a reduction in dendritic cell (DC) accumulation and activation in males, and reduced tissue immunity. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

8 Samples

Download data: CSV, MTX, RDS, TSV

(Submitter supplied) Males and females exhibit profound differences in immune responses and disease susceptibility. However, the factors responsible for sex differences in tissue immunity remain poorly understood. Here, we uncover a dominant role for type 2 innate lymphoid cells (ILC2) in shaping sexual immune dimorphism within the skin. Mechanistically, negative regulation of ILC2 by androgens leads to a reduction in dendritic cell (DC) accumulation and activation in males, and reduced tissue immunity. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

16 Samples

Download data: TXT

(Submitter supplied) Increasing evidence suggests the liver as to be an effector against blood-stage malaria. Vaccination induces changes in the liver and survival of otherwise lethal blood-stage malaria of Plasmodium chabaudi which is associated with changes in the liver. Here, the time-course of expression of erythroid genes is investigated during infections with P. chabaudi in the liver of vaccination-protected and unprotected non-vaccinated mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

30 Samples

Download data: TXT