Similar studies for GEO DataSets (Select 2766) - GEO DataSets

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Items: 2

Select item 27661.

Dominant negative cJun effect on apolipoprotein E deficient livers

Analysis of apolipoprotein E deficient livers from animals expressing a dominant negative cJun (dn-c-Jun). Lipoproteins transport cholesterol and other fats through the bloodstream. Results provide insight into the pathways involved in regulating plasma cholesterol that are affected by dn-c-Jun.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent sets

Platform:: GPL1261
Series:: GSE6850
10 Samples

Download data: CEL

DataSet

Accession:: GDS2766

ID:: 2766

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000068502.

A dominant negative form of cJun affects genes that have opposing effects on lipid homeostasis in mice

(Submitter supplied) cJun is a transcription factor activated by phosphorylation by SAPK/JNK MAP kinase pathway that has been linked to atherosclerosis. Adenovirus mediated gene transfer of a dominant negative form of cJun in C57BL/6 mice increased greatly the apolipoprotein E (ApoE) mRNA and plasma apoE levels and induced dyslipidmia, characterized by increased plasma cholesterol, triglyceride and VLDL levels and accumulation of discoidal HDL particles. more...