Similar studies for GEO DataSets (Select 2863) - GEO DataSets

Warning: The NCBI web site requires JavaScript to function. more...

Format

Summary
Summary (text)
Unique Identifier List

Sort by

Default order
Number of Samples (High to Low)
Number of Samples (Low to High)

Send to:

Choose Destination

File
Clipboard
Collections

Links from GEO DataSets

Items: 2

Select item 28631.

Tienilic acid effect on the liver: time course

Analysis of livers from animals 6 and 24 hours following treatment with tienilic acid. Results provide insight into the molecular basis of tienilic acid associated hepatotoxicity.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, transformed count, 2 agent, 2 time sets

Platform:: GPL1355
Series:: GSE8252
6 Samples

Download data: CEL, CHP, DAT, EXP

DataSet

Accession:: GDS2863

ID:: 2863

Select item 2000082522.

Acute Gene Induction by Tienilic Acid in the Male Sprague Dawley Rat: Possible Role for Danger

(Submitter supplied) Tienilic acid (TA) was withdrawn from the US market due to numerous cases of liver necrosis. Two major hypotheses currently used to understand the mechanisms of idiosyncratic reactions such as TA-induced hepatotoxicity are the hapten and danger hypotheses. Both human cytochrome (CYP) P450 2C9 and the rat ortholog CYP 2C11 metabolize TA, and it was reported that a reactive metabolite of TA binds almost exclusively to these enzymes, thus acting as a mechanism-based inhibitor. more...