Similar studies for GEO DataSets (Select 2877) - GEO DataSets

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Items: 2

Select item 28771.

Chlamydia psittaci infection and host genetic background

Analysis of peritoneal lavage from inbred C57BL/6J and DBA/2J animals 3 days after intraperitoneal injection with Chlamydia psittaci. C57BL/6J are more resistant to C. psittaci infection than DBA/2J. Results provide insight into the genetic basis of this difference.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 strain sets

Platform:: GPL1261
Series:: GSE7767
6 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS2877

ID:: 2877

Select item 2000077672.

Differential transcription of ip Chlamydia infected C57BL6J and DBA2J mice

(Submitter supplied) C57BL/6J mice were 105-fold more resistant to Chlamydia psittaci infection than DBA/2J mice by LD100 determinations. Linkage analysis using BXD recombinant inbred strains revealed a single effector locus at a 1.5 Mbp region on chromosome 11 encoding a cluster of three p47GTPases (Irgb10, Igtp, and Iigp2). Western blots of infected tissue showed that Irgb10 was elevated in resistant mice and one of the two possible Iigp2 protein isoforms was preferentially expressed in susceptible mice. more...