Similar studies for GEO DataSets (Select 2991) - GEO DataSets

Select item 29911.

Analysis of mutant larvae defective for uroporphyrinogen decarboxylase (UROD) at 56 to 96 hours post-fertilization (hpf). UROD is the fifth enzyme in heme biosynthesis. The UROD mutant is a model for hepatoerythropoietic porphyria (HEP). Results provide insight into the pathogenesis of HEP.

Organism:: Danio rerio

Type:: Expression profiling by array, count, 4 age, 2 genotype/variation sets

Platform:: GPL5692
Series:: GSE8651
8 Samples

Download data: TXT

DataSet

Accession:: GDS2991

ID:: 2991

Select item 2000086512.

Transcriptome analysis of zebrafish yquem/urod mutant

(Submitter supplied) Zebeafish yquem harbors a mutation in the gene encoding uroporphyrinogen decarboxylase (UROD), the fifth enzyme in heme biosynthesis, and was established as a vertebrate model for human hepatoerythropoietic porphyria (HEP). In an effort to investigate the unknown aspects of UROD deficiency pathogenesis, we used a 14,000-oligonucleotide-gene microarray to determine differentially expressed genes in yquem/urod (-/-) and wild type control zebrafish larvae. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Dataset:: GDS2991
Platform:: GPL5692
8 Samples

Download data: TXT

Series

Accession:: GSE8651

ID:: 200008651

Select item 2000342963.

LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9185
6 Samples

Download data: TXT, WIG

Series

Accession:: GSE34296

ID:: 200034296

PubMed Full text in PMC Similar studies

Select item 2000342954.

LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function [ChIP-Seq]

(Submitter supplied) We have determined the cistrome and transcriptome for the nuclear receptor liver receptor homolog-1 (LRH-1) in the exocrine pancreas. Chromatin immunoprecipitation (ChIP)-seq and RNA-seq analyses reveal that LRH-1 directly induces expression of genes encoding digestive enzymes and secretory and mitochrondrial proteins. LRH-1 cooperates with the pancreas transcription factor 1-L complex (PTF1-L) in regulationg exocrine pancreas-specific gene expression. more...