GEO DataSets

Analysis of male and female lungs at various time points up to 40 days post-infection with Seoul hantavirus. Males and females differ in their susceptibility to several RNA and DNA viruses. Results provide insight into the influence of gender in the response to Seoul hantavirus infections.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 gender, 2 infection, 4 time sets

Platform:

GPL341

Series:

GSE7271

24 Samples

Download data: CEL

(Submitter supplied) Gene expression profiles were examined in whole lung tissue collected from male and female Long-Evans rats at different time points after inoculation with Seoul virus (i.e., the species-specific hantavirus that infects Norway rats) We used microarray analyses to analyze global gene expression differences between the sexes during hantavirus infection Keywords: time course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3050

Platform:

GPL341

24 Samples

Download data: CEL

(Submitter supplied) In the field, adult male rodents are more frequently infected with hantaviruses than females. Early data suggests that sex steroid hormones modulate sex differences in host immune response. This project focuses on elucidating sex differences in gene expression in the lungs of infected males 15 and 40 days post infection with Seoul virus (naturally occurring hantavirus in Norway rats) relative to infected females 15 and 40 days post infection on 12 RG_U34 GeneChips. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS62

Platform:

GPL85

12 Samples

Download data: CEL

Gene expression in lungs of males 15 and 40 days post-infection with Seoul hantavirus compared with females. Part of an investigation into whether sex steroid hormones modulate sex differences in host immune response.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 gender, 3 infection sets

Platform:

GPL85

Series:

GSE488

12 Samples

Download data: CEL

(Submitter supplied) Orthohantaviruses are viruses generally carried by rodents in which they do not cause overt disease. Seoul orthohantavirus (SEOV) predominantly exists as a persistent infection in the omnipresent reservoir host, the Norway rat, Rattus norvegicus. Upon respiratory transmission via aerosolized infectious rodent excreta to humans, SEOV causes an acute disease named hemorrhagic fever with renal syndrome (HFRS). more...

Organism:

Homo sapiens; Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL18694 GPL16791

24 Samples

Download data: TSV

(Submitter supplied) Purpose: The goals of this study are to compare Next-generation sequencing (NGS)-derived transcriptome profiling (RNA-seq) in the lung of three tyeps of mice during influenza infection. Methods: Total RNA from lung was extracted using a modified TRIzol protocol and spectrophometrically quantitated. Library preparation and sequencing were conducted using 3’ inTAG next-generation sequencing . Differential gene expression for day 6 post influenza infection was determined relative to mock inoculated mice. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

36 Samples

Download data: TXT

(Submitter supplied) The goal of this study was to examine whether immune responses to Plasmodium chabaudi infection differ between the sexes and are altered by the presence of gonadal steroids. Gonadally-intact males were more likely than intact females to die following P. chabaudi infection, exhibit slower recovery from infection-associated weight loss, hypothermia, and anemia, have reduced IFNγ-associated gene expression and IFNγ production during peak parasitemia, and produce less antibody during the recovery phase of infection. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2524

Platform:

GPL339

48 Samples

Download data: CEL

Analysis of white blood cells (WBCs) isolated from spleens of intact and gonadectomized (gdx) males and females up to 14 days after inoculation with Plasmodium chabaudi. Results provide insight into molecular mechanisms mediating the sexual dimorphism in resistance to blood-stage malaria infection.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 disease state, 2 gender, 2 protocol, 4 time sets

Platform:

GPL339

Series:

GSE4324

48 Samples

Download data: CEL