GEO DataSets

Analysis of neonatal ventricular cardiomyocytes subjected to both biomechanical stretch stress and pharmacological (i.e., phenylephrine, PE) induction of hypertrophy. Results provide insight into how mechanical stress is sensed and transduced in cardiomyocytes on the molecular level.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 3 protocol sets

Platform:

GPL1355

Series:

GSE5996

6 Samples

Download data: CEL

(Submitter supplied) Neonatal rat ventricular cardiomyocytes (NRVCMs) were stretched biaxially (112%/24h) or stimulated with phenylephrine (PE, 50 uM), both resulting in a similar degree of hypertrophy. Unstretched NRVCMs served as negative control. Affymetrix microarray analysis revealed 164 genes more than 2.0-fold up- and 21 genes less than 0.5-fold downregulated (p<0.01). Differential expression was confirmed by real-time PCR. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3117

Platform:

GPL1355

6 Samples

Download data: CEL

(Submitter supplied) Rat neonatal cardiomyocytes have been used to study the effect of (pro-) renin binding upon intracellular messenger systems, hypothesized via IGF2/mannoste 6 phosphate (M6P) -receptors and/or ATP6AP2/(pro)renin receptors, opposed to kidney cells. We have used DNA microarray technology to characterize and compare the expression of over 4800 genes in these cells. Gene expression differences were verified using RT-PCR and indicate the presence of cellular activation upon prorenin bindng, non-overlapping with AT-receptor activation. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL3410

6 Samples

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(Submitter supplied) Cardiac hypertrophy is associated with growth and functional changes of cardiomyocytes,including mitochondrial alterations, but the latter are still poorly understood. Here we investigated mitochondrial function and dynamic localization in neonatal rat ventricular cardiomyocytes (NRVCs) stimulated with insulin like growth factor 1 (IGF1) or phenylephrine (PE), mimicking physiological and pathological hypertrophic responses,respectively. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL11534

12 Samples

Download data: CEL

(Submitter supplied) The effect of cyclic mecanical stretch on cardiac gene expression was studied in neonatal rat ventricular myocytes (NRVMs).

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

35 Samples

Download data: CEL, CHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Murid gammaherpesvirus 4; Betapolyomavirus hominis; Rattus norvegicus; human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae

Type:

Non-coding RNA profiling by array

Platform:

GPL7722

20 Samples

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(Submitter supplied) The effect of cyclic mecanical stretch on cardiac microRNA expression was studied in neonatal rat ventricular myocytes (NRVMs).

Organism:

Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; human gammaherpesvirus 4; Betapolyomavirus macacae; Murid gammaherpesvirus 4; Rattus norvegicus; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus hominis

Type:

Non-coding RNA profiling by array

Platform:

GPL7722

9 Samples

Download data: XLS

(Submitter supplied) The effect of cyclic mecanical stretch on cardiac microRNA expression was studied in neonatal rat ventricular myocytes (NRVMs).

Organism:

Homo sapiens; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Mus musculus; Human gammaherpesvirus 8; Human alphaherpesvirus 1; human gammaherpesvirus 4; Betapolyomavirus macacae; Rattus norvegicus; JC polyomavirus; Murid gammaherpesvirus 4; Betapolyomavirus hominis

Type:

Non-coding RNA profiling by array

Platform:

GPL7722

11 Samples

Download data: XLS

(Submitter supplied) Gene expression changes in neonatal rat ventricular myocytes plated in fibronectin (2 samples) or uncoated plates (2 samples). Keywords = Hypertrophy Cardiac Myocyte Fibronectin Keywords: repeat sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS696

Platform:

GPL341

4 Samples

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Examination of neonatal ventricular myocytes plated on fibronectin coated dishes. Fibronectin elicits a hypertrophic response by clustering integrin receptors. Results provide insight into molecular events underlying cardiac hypertrophy.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL341

Series:

GSE1055

4 Samples

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(Submitter supplied) Several different mechanical signals have been proposed to control the extent and pattern of myocardial growth and remodeling, though this has largely been studied using in vitro model systems that are not representative of intact myocardium or in vivo models in which isolating the effects of individual candidate stimuli is exceedigly difficult. We used a unique tissue culture system that allows the simultaneous control of multiple mechanical inputs and other potentially confounding stimuli (e.g., hormonal). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

12 Samples

Download data: CEL, TXT

(Submitter supplied) Aortic valve regurgitation (AR) imposes a severe volume overload to the left ventricle (LV) which results in dilation, eccentric hypertrophy and eventually loss of function. Little is known about the impact of AR on LV gene expression. We therefore conducted a gene expression profiling study in the LV of male Wistar rats with chronic (9 months) and severe AR.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6101

10 Samples

Download data: TXT

(Submitter supplied) Cardiac hypertrophy was induced by aortic banding (6, 12, 16, and 30 weeks), myocardial infarction (3 and 9 weeks), an av-fistula (aorta abd. to v. cava inf.. 3 and 8 weeks), or hormone infusion (two weeks either angiotensin 2 or a thyroxin analogue). Sham operated or saline infused animals served as controls. Gene expression was determined by Affymetrix RGU34A GeneChip's to identify genes with common regulation in the different models of cardiac hypertrophy. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS598

Platform:

GPL85

46 Samples

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Analysis of heart left ventricle tissue in several models of cardiac hypertrophy. Hypertrophy induced by aortic banding, myocardial infarction, an arteriovenous fistula, or hormone (angiotensin 2 or thyroxin analog) infusion.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 disease state, 10 protocol, 9 time sets

Platform:

GPL85

Series:

GSE738

46 Samples

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