GEO DataSets

Analysis of retinas from dark adapted animals following acute exposure to visible light to induce photoreceptor death. Results compared with those from retinas of prCAD mutants, a model for photoreceptor degeneration (GDS3186).

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL1261

Series:

GSE10528

6 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

12 Samples

Download data: CEL

(Submitter supplied) This experiment was designed to identify transcripts that exhibit changes in abundance in the context of retinal degeneration by comparing transcript levels in adult wild type and prCAD -/- mouse retinas. Keywords: genetic mutant analysis

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3186

Platform:

GPL1261

6 Samples

Download data: CEL

(Submitter supplied) Transcriptional profiles were compared between dark adapted and light damaged BALBc (albino) mouse retinas. Keywords: stress response

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3187

Platform:

GPL1261

6 Samples

Download data: CEL

Analysis of retinas from adult protocadherin 21 (prCAD) mutants. The prCAD mutant is a model for inherited photoreceptor degeneration. prCAD is required for the assembly and integrity of the photoreceptor outer segment. Results compared with those from light damaged retinas (GDS3187).

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE10535

6 Samples

Download data: CEL

(Submitter supplied) Expression of the Endothelin-2 (Edn2) mRNA is greatly increased in the photoreceptors (PRs) of mouse models of inherited PR degeneration. To identify retinasl gene whose expression is directly or indirectly regulated by EDN2 in the presence of the Tg(RHO P347S) mutant allele, we defined mRNAs that were differentially expressed in Edn2+/+, Edn2-/-, Tg(RHO P347S) Edn2+/+, and Tg(RHO P347S) Edn2-/- retinas.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

16 Samples

Download data: CEL

(Submitter supplied) Endothelin signaling is required for neural crest migration and homeostatic regulation of blood pressure. Here we report that constitutive over-expression of Endothelin-2 (Edn2) in the mouse retina perturbs vascular development by inhibiting endothelial cell (EC) migration across the retinal surface and subsequent EC invasion into the retina. Developing endothelial cells exist in one of two states: tip cells at the growing front, and stalk cells in the vascular plexus behind the front. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

8 Samples

Download data: CEL, TXT

(Submitter supplied) Rat Retinal Müller cells from diabetic rats (diabetes duration 6 months) compared to Rat Retinal Müller cells from healthy rats. Diabetes was induced by streptozotozine. Diabetic rats were treated with small doses of insulin to prevent catabolism. Keywords: ordered

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

5 Samples

Download data: CEL, EXP

(Submitter supplied) Blood was sampled from severe burns patients over time as well as healthy subjects. Genome-wide expression analyses were conducted using the Affymetrix U133 plus 2.0 GeneChip™. The Inflammation and the Host Response to Injury Large-Scale Collaborative Research Program

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

590 Samples

Download data: CEL