GEO DataSets

Analysis of cultured sebaceous gland cells (SEB-1 sebocytes) treated with 13-cis retinoic acid (13-cis RA, isotretinoin), a potent acne treatment agent that reduces the size and secretion of sebaceous glands. Results provide insight into the molecular basis for 13-cis RA's acne-clearing effect.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL8300

Series:

GSE10432

6 Samples

Download data: CEL

(Submitter supplied) The pathogenesis of acne has been linked to multiple factors such as increased sebum production, inflammation, follicular hyperkeratinization, and the action of Propionibacterium acnes within the follicle. 13-cis Retinoic Acid (13-cis RA, isotretinoin) is the most potent agent in acne treatment. Surprisingly, its mechanism of action in acne is still unknown. Gene expression profiling of cultured human immortalized sebocytes (SEB-1) treated with 13-cis RA was performed to gain insights into its sebocyte-specific mechanism of action. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL571 GPL8300

18 Samples

Download data: CEL

(Submitter supplied) The pathogenesis of acne has been linked to multiple factors such as increased sebum production, inflammation, follicular hyperkeratinization, and the action of Propionibacterium acnes within the follicle. 13-cis Retinoic Acid (13-cis RA, isotretinoin) is the most potent agent in acne treatment. Surprisingly, its mechanism of action in acne is still unknown. Gene expression profiling of skin from 6 patients treated with isotretinoin was performed to gain insights into its mechanism of action. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3218

Platform:

GPL571

12 Samples

Download data: CEL

(Submitter supplied) The pathogenesis of acne has been linked to multiple factors such as increased sebum production, inflammation, follicular hyperkeratinization, and the action of Propionibacterium acnes within the follicle. 13-cis Retinoic Acid (13-cis RA, isotretinoin) is the most potent agent in acne treatment. Surprisingly, its mechanism of action in acne is still unknown. Gene expression profiling of cultured human immortalized sebocytes (SEB-1) treated with 13-cis RA was performed to gain insights into its sebocyte-specific mechanism of action. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3215

Platform:

GPL8300

6 Samples

Download data: CEL

Analysis of upper back skin biopsies of acne patients treated with 13-cis retinoic acid (13-cis RA, isotretinoin), a potent acne treatment agent that reduces the size and secretion of sebaceous glands. Results provide insight into the molecular basis for 13-cis RA's acne-clearing effect.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 6 individual sets

Platform:

GPL571

Series:

GSE10433

12 Samples

Download data: CEL

(Submitter supplied) To help elucidate the metabolic changes in the skin that contribute to the obesity resistance and skin pathology in mice lacking Scd1, we performed microarray analysis of skin gene expression in male skin Scd1 knockout (SKO) and Scd1 flox/flox control (Lox) mice fed a standard rodent diet. We identified an extraordinary number of differentially expressed genes that support the previously documented histological observations of sebocyte atrophy, inflammation and epidermal hyperplasia in SKO mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4910

Platform:

GPL1261

6 Samples

Download data: CEL

Analysis of skins of animals with skin-specific deletion of Scd1. Animals with skin-specific deletion of Scd1 develop severe sebaceous gland hypoplasia that results in progressive scarring alopecia. Results provide insight into the molecular basis of Scd1-deficient skin pathology

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE24243

6 Samples

Download data: CEL

(Submitter supplied) The pathogenesis of acne has been linked to multiple factors such as increased sebum production, inflammation, follicular hyperkeratinization, and the action of Propionibacterium acnes within the follicle. 13-cis Retinoic Acid (13-cis RA, isotretinoin) is the most potent agent in acne treatment. Surprisingly, its mechanism of action in acne is still unknown. Gene expression profiling of skin from 8 patients treated with isotretinoin was performed to gain insights into its mechanism of action. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

16 Samples

Download data: CEL