GEO DataSets

Bone marrow-derived macrophages from mice that had received fetal liver cells from SOCS3+/+ or SOCS3-/- embryos analyzed. Macrophages either unstimulated, or stimulated for 100 or 400 minutes with 10 ng/ml IL-6.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 strain, 3 time sets

Platform:

GPL81

Series:

GSE411

17 Samples

Download data: CEL

(Submitter supplied) Effects of SOCS3 on the transcriptional response of bone marrow-derived macrophages to IL-6. Fetal liver cells from SOCS3+/+ or SOCS3-/- embryos were used to reconstitute recipient mice. Donor derived bone marrow from these mice was differentiated to macrophages. Macrophages were either unstimulated, or stimulated for 100 or 400 minutes with 10 ng/ml IL-6. Keywords = macrophage, SOCS3, IL-6, interferon Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS325

Platform:

GPL81

17 Samples

Download data: CEL

(Submitter supplied) Changes in mouse liver mRNA profiles following intraperitoneal cytokine injection. Either interferon-gamma-/-, albumin-cre(-) Socs3(w/fl) mice, or albumin-cre(+) Socs3(-/fl) mice were injected with either phosphate-buffered saline, interferon-gamma, or interfeukin-6, and livers taken after 4h. Keywords = Socs3, interferon gamma, interleukin-6, il6, liver, suppressor of cytokine signalling 3 Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS280

Platform:

GPL81

12 Samples

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Liver mRNA profiles following intraperitoneal cytokine injection. Strains interferon gamma -/-, albumin-cre(-) Socs3(w/fl) and albumin-cre(+) Socs3(-/fl) injected with either PBS, interferon gamma, or interleukin 6, and liver examined at 4 hours.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 agent, 3 strain sets

Platform:

GPL81

Series:

GSE369

12 Samples

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(Submitter supplied) Timecourse analysis of Interferon-Gamma (IFNg) signalling in mice deficient for IFNg or both IFNg and Suppressor of Cytokine Signalling-1 (SOCS1). Keywords: time course expression analysis

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1957

Platform:

GPL81

22 Samples

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Analysis of the effect of interferon gamma (IFNg) on the livers of animals lacking IFNg, or both suppressor of cytokine signaling-1 (SOCS1) and IFNg. Gene expression examined up to 48 hours following IFNg treatment. Results provide insight into the role of SOCS1 in regulating the response to IFNg.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 agent, 2 genotype/variation, 9 time sets

Platform:

GPL81

Series:

GSE4232

22 Samples

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(Submitter supplied) Suppressor of cytokine signaling 3 (SOCS3) down-regulates several signaling pathways in multiple cell types, and previous data suggest that SOCS3 may shut off cytokine activation at the early stages of liver regeneration. We developed hepatocyte-specific Socs3 knockout (Socs3 h-KO) mice to directly study the role of SOCS3 during liver regeneration after 2/3 partial hepatectomy (PH). Socs3 h-KO mice demonstrate marked enhancement of DNA replication and liver weight restoration after 2/3 PH in comparison with littermate controls. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3149

Platform:

GPL1261

6 Samples

Download data: CEL

Analysis of regenerating livers of animals bearing a hepatocyte-specific Suppressor of cytokine signaling 3 gene (SOCS3) knockout. SOCS3 down-regulates several signaling pathways in multiple cell types. Results provide insight into the role of SOCS3 in liver regeneration.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE9549

6 Samples

Download data: CEL

(Submitter supplied) IL-10 regulates anti-inflammatory signaling via the activation of STAT3, which in turn controls the induction of a gene expression program whose products execute inhibitory effects on pro-inflammatory mediator production. Here we show that IL-10 induces the expression of an ETS family transcriptional repressor, ETV3 and a helicase family co-repressor, SBNO2 (Strawberry notch homolog 2) in mouse and human macrophages. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3190

Platform:

GPL1261

18 Samples

Download data: CEL

Analysis of interleukin-10 (IL-10)-deficient macrophages at various time points up to 30 minutes following co-stimulation with lipopolysaccharide (LPS) and IL-10. LPS elicits an inflammatory response. Results provide insight into molecular mechanisms underlying the anti-inflammatory effect of IL-10.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 3 time sets

Platform:

GPL1261

Series:

GSE9509

18 Samples

Download data: CEL