GEO DataSets

Analysis of germinal vesicle (GV)-intact oocytes and metaphase II (MII) eggs obtained from young and old females. An increased incidence of aneuploidy is observed with increasing maternal age. Results provide insight into the molecular basis underlying the age-associated increase in aneuploidy.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 age, 2 development stage sets

Platform:

GPL1261

Series:

GSE11667

16 Samples

Download data: CEL

(Submitter supplied) An increase in the incidence of aneuploidy is well documented with increasing maternal age, in particular in human females. Remarkably, little is known regarding the underlying molecular basis for the age-associated increase in aneuploidy, which is a major source of decreased fertility in humans. Using mouse as a model system we find that eggs obtained from old mice (60-70 weeks of age) display a 6-fold increase in the incidence of hyperploidy as assessed by chromosome spreads. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3295

Platform:

GPL1261

16 Samples

Download data: CEL

(Submitter supplied) Decreasing oocyte competence with maternal aging is a major factor in human infertility. To investigate the age-dependent molecular changes in a mouse model, we compared the expression profiles of metaphase II oocytes collected from 5-6 week old mice with those collected from 40-42 week old mice using the NIA 22K 60-mer oligo microarray. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL870

12 Samples

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