GEO DataSets

Analysis of kidneys from C57Bl transgenics expressing human fibroblast growth factor-23 (FGF23). FGF23 is a circulating protein that causes decreased renal inorganic phosphate (Pi) reabsorption. Results provide insight into molecular mechanisms underlying the regulation of Pi homeostasis by FGF23.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 strain sets

Platform:

GPL81

Series:

GSE6979

10 Samples

Download data: CEL, EXP

(Submitter supplied) Fibroblast growth factor-23 (FGF23), a circulating protein produced in bone, causes renal inorganic phosphate (Pi) wasting by down-regulation of sodium phosphate co-transporter 2a (Npt2a). The mechanism behind this action is unknown. We have previously generated transgenic mice (TG) expressing human wild-type FGF23 under the control of the α1 (I) collagen promoter. In this study we performed a large scale gene expression study of kidneys from TG mice and wild-type littermates. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3361

Platform:

GPL81

10 Samples

Download data: CEL, EXP

(Submitter supplied) Every individual (W1-W4) was hybridised 4 times, including 2 dye swaps: W1: 23573-23576; W2: 23577-23580; W3: 23581-23584; W4: 23585-23588. Only 2 of 4 hybridisations wer made at the same preparation Keywords: parallel sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1216

16 Samples

Download data

(Submitter supplied) Every individual kidney was hybridised 4 times including 2 dye swaps: K1: 23557-23560 K2: 23561-23564 K3: 23565-23568 K4: 23569-23572 Only 2 of 4 hybridisations were made at one sample preparation. Keywords: parallel sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1216

16 Samples

Download data

(Submitter supplied) Phosphate homeostasis is a known critical function performed by the mammalian kidneys. However, changes to the transcriptome of the mammalian kidney in response to phosphate loading is unclear. The goal of this study was to examine kidney gene expression in response to high phosphate diet, compared to normal phosphate diet. RNA-seq was performed on the kidneys of C57BL/6J mice who were fed a high phosphate diet and in mice who received a normal phosphate diet for three days.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28457

8 Samples

Download data: XLSX

(Submitter supplied) One of the main regulators of phosphate homeostasis is fibroblast growth factor 23 (FGF23), secreted by osteocytes. The effects of organic versus inorganic dietary phosphate on this homeostasis is unclear. This study used MC3T3-E1 osteocyte-like cells to examine the transcriptomic responses to these phosphates. Most importantly, the expression and secretion of FGF23 was only increased in response to organic phosphate. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

9 Samples

Download data: TXT

(Submitter supplied) FGF23 has been known to play an important role of calcium-phosphorus (Ca-P) metabolism. Recently, biological roles of FGF23 other than Ca-P metabolism were reported, such as commitment to myocardium enlargement and immunological roles in spleen. Thus, it was thought FGF23 might have roles other than Ca-P metabolism in renal tubule epithelial cells. So, we tried to identify new biological roles of FGF23 in those cells using DNA microarray analysis in mouse renal tubule epithelial cell line, mIMCD3, with FGF23 stimulation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13912

2 Samples

Download data: TXT, XLSX