GEO DataSets

Comparison of the Rickettsia rickettsii virulent strain Sheila Smith and the avirulent strain Iowa. R. rickettsii is an obligate intracellular pathogen that causes Rocky Mountain spotted fever. Results provide insight in the molecular basis of virulence in R. rickettsii.

Organism:

Coxiella burnetii; Rickettsia rickettsii; Chlamydia muridarum; Chlamydophila pneumoniae AR39; Staphylococcus epidermidis RP62A; Staphylococcus epidermidis ATCC 12228; Staphylococcus aureus subsp. aureus MW2; Borrelia burgdorferi B31; Coxiella burnetii RSA 493; Chlamydophila caviae GPIC; Chlamydia trachomatis D/UW-3/CX; Staphylococcus haemolyticus JCSC1435; Granulibacter bethesdensis

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL4692

Series:

GSE8041

6 Samples

Download data: CEL, CHP

(Submitter supplied) Comparison of gene expression between the virulent Rickettsia rickettsii R strain and avirulent Rickettsia rickettsii Iowa. Keywords: virulent vs avirulent

Organism:

Chlamydia pneumoniae AR39; Borreliella burgdorferi B31; Coxiella burnetii RSA 493; Granulibacter bethesdensis; Chlamydia trachomatis D/UW-3/CX; Staphylococcus epidermidis ATCC 12228; Staphylococcus aureus subsp. aureus MW2; Coxiella burnetii; Rickettsia rickettsii; Chlamydia muridarum; Staphylococcus epidermidis RP62A; Chlamydia caviae GPIC; Staphylococcus haemolyticus JCSC1435

Type:

Expression profiling by array

Dataset:

GDS3427

Platform:

GPL4692

6 Samples

Download data: CEL, CHP

(Submitter supplied) Members of the spotted fever group rickettsia express four large, surface-exposed autotransporters, at least one of which is a known virulence determinant. Autotransporter translocation to the bacterial outer surface, also known as type V secretion, involves formation of a b-barrel autotransporter domain in the periplasm that inserts into the outer membrane to form a pore through which the N-terminal passenger domain is passed and exposed on the outer surface. more...

Organism:

Rickettsia rickettsii; Chlorocebus aethiops

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL33219 GPL33220

24 Samples

Download data: TSV

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rickettsia rickettsii

Type:

Expression profiling by array

Platform:

GPL16681

8 Samples

Download data

(Submitter supplied) One of the most important vectors of the Brazilian Spotted Fever, the tick Amblyomma aureolatum in Brazil was used in this study. We laboratorial controlled the infection of adult females of A. aureolatum with the virulent brazilian strain Taiacu of Rickettsia rickettsii. The group of ticks was divided into 2 testing groups, group 1 (G1) composed of adult females incubated at 25°C for 3 days and group 2 (G2) composed of adult females incubated at 35°C for 3 days. more...

Organism:

Rickettsia rickettsii

Type:

Expression profiling by array

Platform:

GPL16681

4 Samples

Download data

(Submitter supplied) One of the most important vectors of the Brazilian Spotted Fever, the tick Amblyomma aureolatum in Brazil was used in this study. We laboratorial controlled the infection of adult females of A. aureolatum with the virulent brazilian strain Taiacu of Rickettsia rickettsii. The group of ticks was divided into 2 testing groups, group 2 (G2) composed of adult females incubated at 35°C for 3 days that were not fed after molting to adults and group 3 (G3) composed of adult females fed on its favorite natural host, the dog (Canis familiaris) also for 3 days. more...

Organism:

Rickettsia rickettsii

Type:

Expression profiling by array

Platform:

GPL16681

4 Samples

Download data

(Submitter supplied) Rickettsiae are strict obligate intracellular pathogens that alternate between arthropod and mammalian hosts in a zoonotic cycle. Typically, pathogenic bacteria that cycle between environmental sources and mammalian hosts adapt to the respective environments by coordinately regulating gene expression such that genes essential for survival and virulence are expressed only upon infection of mammals. Temperature is a common environmental signal for upregulation of virulence gene expression although other factors may also play a role. more...

Organism:

Chlamydia pneumoniae AR39; Coxiella burnetii RSA 493; Chlamydia caviae GPIC; Granulibacter bethesdensis; Staphylococcus aureus subsp. aureus MW2; Staphylococcus haemolyticus JCSC1435; Coxiella burnetii; Rickettsia rickettsii; Chlamydia muridarum; Staphylococcus epidermidis RP62A; Staphylococcus epidermidis ATCC 12228; Borreliella burgdorferi B31; Chlamydia trachomatis D/UW-3/CX

Type:

Expression profiling by array

Platform:

GPL4692

97 Samples

Download data: CEL, CHP

(Submitter supplied) We identified four virulence phenotypes of Rickettsia prowazekii (the deadly agent of epidemic typhus) that are associated with the upregulation of antiapoptotic genes (virulent strain) or the Interferon I pathway (avirulent). Transcriptional and proteomic analyses of R. prowazekii linked surface protein expression and methylation with virulence. By sequencing a virulent strain and using comparative genomics, we found hotspots of mutations in homopolymeric tracts of poly(A) and poly(T) that lead to gene split and inactivation and explain the loss of virulence in the vaccine strain. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3848

Platform:

GPL4133

16 Samples

Download data: TXT

(Submitter supplied) We identified four virulence phenotypes of Rickettsia prowazekii (the deadly agent of epidemic typhus) that are associated with the upregulation of antiapoptotic genes (virulent strain) or the Interferon I pathway (avirulent). Transcriptional and proteomic analyses of R. prowazekii linked surface protein expression and methylation with virulence. By sequencing a virulent strain and using comparative genomics, we found hotspots of mutations in homopolymeric tracts of poly(A) and poly(T) that lead to gene split and inactivation and explain the loss of virulence in the vaccine strain. more...

Organism:

Rickettsia prowazekii str. Rp22; Rickettsia prowazekii str. Madrid E; Rickettsia prowazekii

Type:

Expression profiling by array

Platform:

GPL8427

3 Samples

Download data: TXT

Analysis of endothelial cells infected by R. prowazekii strains (Erus, Evir, Rp22) of varying virulence. Virulent R. prowazekii causes epidemic typhus and avirulent strains can revert to virulence. Results provide insight into the molecular basis of virulence and adaptive mutation in R. prowazekii.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 strain sets

Platform:

GPL4133

Series:

GSE16123

16 Samples

Download data: TXT