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Links from GEO DataSets

Items: 6

1.
Full record GDS3517

Oncogenic NRAS depletion effect on melanoma cell lines: time course

Analysis of melanoma 224 and BL cells for up to 3 days after suppression of the mutant NRAS Q61R gene with siRNA siMut10 or siMut12. Activating mutations in NRAS gene is a common genetic event in malignant melanoma. Results provide insight into the role of NRAS in the pathogenesis of melanoma.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 agent, 2 cell line, 4 time sets
Platform:
GPL96
Series:
GSE12445
51 Samples
Download data: CEL
DataSet
Accession:
GDS3517
ID:
3517
2.

Expression data from melanoma cell lines 224 and BL transfected with siRNA-NRASQ61R

(Submitter supplied) Transcriptional profiling for global characterization of gene expression alterations that resulted from treatment of melanoma cells with siRNA specifically targeting NRASQ61R
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3517
Platform:
GPL96
51 Samples
Download data: CEL
Series
Accession:
GSE12445
ID:
200012445
3.

Affymetrix HG-U133A 2.0 Expression data

(Submitter supplied) Expression .CEL files from Affymetrix HG-U133A 2.0 arrays using DNA from 14 human cell lines derived from metastasized melanoma
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
14 Samples
Download data: CEL
Series
Accession:
GSE22787
ID:
200022787
4.

Oncogenic potential of RAS isoforms in melanocytes

(Submitter supplied) We compared the transformation efficiencies of mutant NRAS and KRAS in immortal, non-transformed Ink4a/Arf-deficient melanocytes. NRAS mutation leads to increased cellular proliferation and is potently tumorigenic. In contrast, KRAS mutation does not enhance melanocyte proliferation and is only weakly tumorigenic on its own. While both NRAS and KRAS activate MAPK signaling, only NRAS enhances MYC activity in these cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4487
12 Samples
Download data: GPR
Series
Accession:
GSE6194
ID:
200006194
5.

Regulators of NRAS-mediated transformation and melanoma tumor maintenance

(Submitter supplied) Mutations in the NRAS oncogene are present in up to 20% of melanoma. Here, we show that interferon alpha-inducible protein 6 (IFI6) is necessary for NRASQ61K-induced transformation and melanoma growth. IFI6 was transcriptionally upregulated by NRASQ61K, and knockdown of IFI6 resulted in DNA replication stress due to dysregulated DNA replication via E2F2. This stress consequentially inhibited cellular transformation and melanoma growth via senescence or apoptosis induction depending on the RB and p53 pathway status of the cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
6 Samples
Download data: TXT
Series
Accession:
GSE69933
ID:
200069933
6.

Transcriptional targets of oncogenic RAS proteins that mediate their ability to induce cellular transformation

(Submitter supplied) Mutations in the NRAS oncogene are present in up to 20% of melanoma. Here, we show that interferon alpha-inducible protein 6 (IFI6) is necessary for NRASQ61K-induced transformation and melanoma growth. IFI6 was transcriptionally upregulated by NRASQ61K, and knockdown of IFI6 resulted in DNA replication stress due to dysregulated DNA replication via E2F2. This stress consequentially inhibited cellular transformation and melanoma growth via senescence or apoptosis induction depending on the RB and p53 pathway status of the cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
12 Samples
Download data: TXT
Series
Accession:
GSE62827
ID:
200062827
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