GEO DataSets

Breast cancer core biopsies taken from patients found to be resistant (greater than 25% residual tumor volume) or sensitive (less than 25% residual tumor volume) to docetaxel treatment.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL8300

Series:

GSE6434

24 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS360

Platform:

GPL8300

24 Samples

Download data: CEL

(Submitter supplied) These patients were sensitive to docetaxel treatment, exhibiting less than 25% residual tumor. Keywords: repeat sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

10 Samples

Download data: CEL

(Submitter supplied) These patients proved resistant to docetaxel treatment, exhibiting residual tumor of 25% or greater remaining volume. Keywords: repeat sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

14 Samples

Download data: CEL

(Submitter supplied) Neoadjuvant chemotherapy has been shown to be equivalent to post-operative treatment for breast cancer, and allows for assessment of chemotherapy response. In a pilot trial of docetaxel (T) and capecitabine (X) neoadjuvant chemotherapy for Stage II/III BC, we assessed correlation between baseline gene expression and tumor response to treatment, and examined changes in gene expression associated with treatment. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

61 Samples

Download data: CEL

(Submitter supplied) Low topo2a expression and ER-negative status were predictors of response to doxorubicin, while small tumor size and ER-negative status predicted response to docetaxel. Docetaxel was superior to doxorubicin in triple-negative/basal-like tumors, while no significant differences between these drugs were seen in the remaining intrinsic subtypes Keywords: reference x sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL5325 GPL1390 GPL7504

98 Samples

Download data

(Submitter supplied) EORTC 10994 phase III breast cancer clinical trial comparing FEC (5-fluorouracil, cyclophosphamide, epirubicin) with ET (epirubicin, docetaxel). 161 needle biopsies of locally advanced or large operable breast tumours were hybridised to Affymetrix X3P chips. The array data from the ER negative tumours (28/65 pathological CR in the FEC arm, 27/59 pathological CR in the ET arm) were used to validate the cell line-based chemotherapy response predictors developed by the Potti/Nevins group at Duke University (doi:10.1038/nm1491). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1352

161 Samples

Download data: CEL

(Submitter supplied) The purpose of this study was to identify molecular markers of pathologic response to neoadjuvant paclitaxel/radiation treatment, protein and gene expression profiling were done on pretreatment biopsies. Patients with high-risk, operable breast cancer were treated with three cycles of paclitaxel followed by concurrent paclitaxel/radiation. Tumor tissue from pretreatment biopsies was obtained from 19 of the 38 patients enrolled in the study. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3721

Platform:

GPL570

28 Samples

Download data: CEL

Analysis of pretreatment breast cancer (BC) tumors from patients enrolled in a paclitaxel/radiation clinical trial. Patients achieved pathologic complete response (pCR) or partial response (pPR). Results provide insight into molecular markers of pathologic response to paclitaxel/RT treatment of BC.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state sets

Platform:

GPL570

Series:

GSE22513

28 Samples

Download data: CEL

(Submitter supplied) Docetaxel-based chemotherapy is the standard first-line therapy in metastatic castration-resistant prostate cancer. However, most patients eventually develop resistance to this treatment. The aim of the study was to identify key molecular genes and networks associated with docetaxel resistance in 2 models of docetaxel-resistant castration-resistant prostate cancer cell lines.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3973

Platform:

GPL570

12 Samples

Download data: CEL

Analysis of prostate cancer cell lines resistant to docetaxel chemotherapy, DU-145R and PC-3R, which were derived from cell lines DU-145 and PC-3, respectively. Results provide insight into the molecular mechanisms underlying docetaxel resistance.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 4 cell line sets

Platform:

GPL570

Series:

GSE33455

12 Samples

Download data: CEL

(Submitter supplied) In a prospective cohort study of 32 women with primary invasive breast cancer with a measurable lesion, we obtained a tumor specimen by high speed core biopsy before and after 4 cycles of NAC with epirubicine 90mg/m2 and cyclophosphamide 600mg/m2 every 3 weeks, followed by 4 cycles of docetaxel 100mg/m2. Total RNA was extracted from tumor specimens and the whole transcriptome was quantified with Agilent’s 44K single color microarray interrogating 41000 unique human genes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

57 Samples

Download data: TXT