GEO DataSets

Analysis of livers from male FVB animals fasting for up to 72 hours. Results provide insight into the adaptive response of the liver to fasting.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 4 time sets

Platform:

GPL922

Series:

GSE10653

12 Samples

Download data: TIFF, TXT

(Submitter supplied) Background In the postabsorptive state, the portal-drained viscera are a major energy consumer, but a comprehensive overview of the adaptive fasting response in the liver is lacking. Hence, gene-expression profiling, pathway, network and gene-set enrichment analysis and immunohistochemistry were carried out on mouse liver after 0, 12, 24, and 72 hours of fasting. Results Liver weight has fallen to 50% of control after three days of fasting, hepatocyte size was reduced with no apparent increase in apoptosis, while the basic liver structure and metabolic zonnation were preserved. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3642

Platform:

GPL922

12 Samples

Download data: TIFF, TXT

(Submitter supplied) Medium-chain acyl-coenzyme A (CoA) dehydrogenase (MCAD) catalyzes crucial steps in mitochondrial fatty acid oxidation, a process that is of key relevance for maintenance of energy homeostasis, especially during high metabolic demand. To gain insight into the metabolic consequences of MCAD deficiency under these conditions, we compared hepatic carbohydrate metabolism in vivo in wild-type and MCAD-/- mice during fasting and during a lipopolysaccharide (LPS)-induced acute phase response (APR). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4546

Platform:

GPL1261

20 Samples

Download data: CEL

Analysis of liver from medium-chain acyl-coenzyme A dehydrogenase-deficient (MCAD-/-) adult males during fasting and during an LPS-induced acute phase response. Results provide insight into the molecular basis of disturbed hepatic carbohydrate management during metabolic stress in MCAD-/- mutants.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 stress sets

Platform:

GPL1261

Series:

GSE37546

20 Samples

Download data: CEL

(Submitter supplied) Transcriptional profiling coupled with blood metabolite analyses were used to identify porcine genes and pathways that respond to a fasting treatment or to a D298N missense mutation in the melanocortin-4 receptor (MC4R) gene. Gilts (12 homozygous for D298 and 12 homozygous for N298) were either fed ad libitum or fasted for 3 days. Fasting decreased body weight and backfat and increased serum concentrations of non-esterified fatty acid and urea. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL3533

48 Samples

Download data: CEL, CHP

(Submitter supplied) Background The gut is a major energy consumer, but a comprehensive overview of the adaptive response to fasting is lacking. Gene-expression profiling, pathway analysis, and immunohistochemistry were therefore carried out on mouse small intestine after 0, 12, 24, and 72 hours of fasting. Results Intestinal weight declined to 50% of control, but this loss of tissue mass was distributed proportionally among the gut’s structural components, so that the microarrays’ tissue base remained unaffected. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL922

12 Samples

Download data: TIFF, TXT

(Submitter supplied) Background: Exposure to dichlorvos (DDVP), an organophosphorus pesticide, is known to result in neurotoxicity as well as other metabolic perturbations. However, the molecular causes of DDVP toxicity are poorly understood, especially in cells other than neurons and muscle cells. To obtain a better understanding of the process of non-neuronal DDVP toxicity, we exposed zebrafish to different concentrations of DDVP, and investigated the resulting changes in liver histology and gene transcription. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL7301

32 Samples

Download data: GPR, TXT

(Submitter supplied) To investigate the global gene expression dynamics associated with short-term fasting, we used mRNA-seq to profile the transcriptomes of nine organs obtained from mice subjected to six different STF duration (0, 2, 8, 12, 18 and 22 hours of fasting; n=3 per time point; Fig. 1a). The nine organs profiled were: olfactory bulb (OB), brain (BRN, which includes the telencephalon and diencephalon), cerebellum (CBL), brainstem (BST, which consists of the mesencephalon, pons, and myelencephalon), stomach (STM), liver (LIV), interscapular brown adipose tissue (iBAT), perigonadal white adipose tissue (pgWAT), and posterior-subcutaneous white adipose tissue (psWAT).

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

162 Samples

Download data: TXT

(Submitter supplied) Complete starvation may prove lethal due to excessive loss of body proteins. However, it is still not completely understood whether responses to food deprivation are time-dependently induced or triggered in relation with the successive phases of protein sparing and wasting that characterize prolonged fasting. As the liver has a wide range of vital functions, we examined the hepatic regulatory mechanisms elicited during prolonged fasting. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6543

16 Samples

Download data: CEL, CHP

(Submitter supplied) The effects of fasting have been studied extensively, predominantly on isolated processes, within a specific organ. No comprehensive study of the adaptations was available for different organs, let alone interrelating them, which left the understanding of the body’s orchestration of fasting response limited. The gene expression profiles of brain, small intestine, kidney, liver and skeletal muscle were therefore studied in mice subjected to short, moderate and prolonged fasting. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3893

Platform:

GPL11012

122 Samples

Download data: TXT

Analysis of brain, small intestine, kidney, liver, and skeletal muscle subjected to 0-72 hrs of fasting. Adapting to starvation requires an interorgan integration of metabolic activity to protect vital organs. Results provide insight into molecular mechanisms underlying this adaptive response.

Organism:

Mus musculus

Type:

Expression profiling by array, log2 ratio, 5 time, 5 tissue sets

Platform:

GPL11012

Series:

GSE24504

122 Samples

Download data: TXT