Similar studies for GEO DataSets (Select 3668) - GEO DataSets

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Items: 2

Select item 36681.

Familial hypercholesterolemia and atherosclerosis: monocytes

Analysis of monocytes (MO) from familial hypercholesterolemia (FH) patients. FH patients have a defective or missing LDLR resulting in atherosclerosis. Atherosclerotic lesions often contain MO-derived, lipid-laden macrophages. Results provide insight into the role of MO in onset of atherosclerosis.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 disease state sets

Platform:: GPL570
Series:: GSE6054
23 Samples

Download data: CEL

DataSet

Accession:: GDS3668

ID:: 3668

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000060542.

Monocytes of patients with familial hypercholesterolemia show alterations in cholesterol metabolism

(Submitter supplied) Background: Elevated plasma cholesterol promotes the formation of atherosclerotic lesions in which monocyte-derived lipid-laden macrophages are frequently found. To analyze, if circulating monocytes already show increased lipid content and differences in lipoprotein metabolism, we compared monocytes from patients with Familial Hypercholesterolemia (FH) with those from healthy individuals. Methods: Cholesterol and oxidized cholesterol metabolite serum levels of FH and of healthy, gender/age matched control subjects were measured by combined gas chromatography ? mass spectroscopy. more...