Similar studies for GEO DataSets (Select 3773) - GEO DataSets

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Items: 2

Select item 37731.

Interleukin 6 effect on liver

Analysis of livers from C57BL6 males treated with IL-6. Cytokines such as IL-6 activate STAT3 which plays a role in glucose homeostasis by negatively regulating hepatic gluconeogenic gene expression. Results provide insight into STAT3 targets involved in the development of metabolic syndrome.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 agent sets

Platform:: GPL6246
Series:: GSE21060
6 Samples

Download data: CEL

DataSet

Accession:: GDS3773

ID:: 3773

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000210602.

Regulation of gene expression in murine liver by IL-6

(Submitter supplied) STEAP4 is a plasma membrane metallo-reductase involved in the transport of iron and copper. Recently, STEAP4 was implicated in promoting insulin sensitivity by acting in white adipose tissue (WAT) to control the production of inflammatory cytokines such as IL-6. Indeed, the loss of STEAP4 expression in mice leads to increased production of inflammatory cytokines in visceral WAT and systemic insulin resistance. more...