GEO DataSets

Analysis of epididymal WAT from C57BL/6J adult males adapted to a high-fat diet for 3 wks, then fed a high-fat diet on an ad-libitum basis (HF-AL) or on a restricted basis (HF-DR) for 12 wks. Results provide insight into molecular mechanisms underlying improved metabolic health induced by HF-DR.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 protocol sets

Platform:

GPL7202

Series:

GSE27213

36 Samples

Download data: TXT

(Submitter supplied) High energy intake and, specifically, high dietary fat intake challenges the mammalian metabolism and correlates with many metabolic disorders, such as obesity and diabetes. Dietary restriction (DR) is, on the other hand, known to prevent the development of metabolic disorders. The current Western diets are highly enriched in fat and it is as yet unclear whether DR on a certain high-fat (HF) diet elicits similar beneficial effects on health. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3986

Platform:

GPL7202

36 Samples

Download data: TXT

(Submitter supplied) We previously reported that a low versus high glycemic index (GI) diet on a high fat (30% kcal fat) background (LGI and HGI, respectively) significantly retarded adverse health effects in C57BL/6J male mice. The LGI diet enhanced whole body insulin sensitivity and repressed high fat diet-induced body and adipose tissue weight gain, resulting in reduced serum leptin and resistin levels (Faseb J 2009; 23: 1092-1101). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7042

17 Samples

Download data: TXT

(Submitter supplied) Germfree (GF) mice have been used as a model to study the contribution of the intestinal microbiota to metabolic energy balance of the host. Despite a wealth of knowledge accumulated since the 1940’s, the response of GF mice to a high fat diet is largely unknown. In the present study, we compared the metabolic consequences of a high fat (HF) diet on GF and conventional (Conv) C57BL/6J mice. As expected, Conv mice developed obesity and glucose intolerance with a HF diet. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6103

30 Samples

Download data: TXT

(Submitter supplied) An 8-week high fat palm oil diet causes obesity and insulin resistance in C57BL/6J mice, but induces only small changes in the muscle transcriptome. Introduction: The metabolic syndrome (MS) is a cluster of metabolic abnormalities linked to an increased risk of type 2 diabetes and cardiovascular diseases. Two major characteristics of the MS are obesity and insulin resistance. In the present study we investigated the effect of obesity and insulin resistance on the mouse muscle transcriptome. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4015

Platform:

GPL7546

30 Samples

Download data: CEL

Analysis of skeletal muscle of C57BL/6J males fed a high fat diet (HFD) for 8 weeks to induce obesity and insulin resistance. Results provide insight into the molecular mechanisms underlying the development of diet-induced obesity and insulin resistance.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 growth protocol, 2 time sets

Platform:

GPL7546

Series:

GSE17576

30 Samples

Download data: CEL

(Submitter supplied) Using standardized, semipurified diets is a crucial factor for reproducibility of experimental nutritional studies. For the purpose of comparability and integration of research, two European consortia, Mitofood and BIOCLAIMS, proposed an AIN-93-based standard reference diet, the standardized BIOCLAIMS low-fat diet (LFD) as well as a high-fat diet (HFD). In order to evaluate the BIOCLAIMS LFD and HFD, we performed short-term (5 days) and long-term (12 weeks) feeding experiments using male C57BL/6 mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10333

40 Samples

Download data: TXT

(Submitter supplied) SCOPE: We investigated whether a novel dietary intervention consisting of an every-other-week calorie-restricted diet could prevent nonalcoholic fatty liver disease (NAFLD) development induced by a medium-fat (MF) diet. METHODS AND RESULTS: Nine-week-old male C57BL/6J mice received either a (i) control (C), (ii) 30E% calorie restricted (CR), (iii) MF (25E% fat), or (iv) intermittent (INT) diet, a diet alternating weekly between 40E% CR and an ad libitum MF diet until sacrifice at the age of 12 months. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11533

27 Samples

Download data: CEL

(Submitter supplied) Background & Aims: In this study, we investigated metabolic and molecular effects of weekly intervening 30% calorie restriction on long term natural progression of non-alcoholic fatty liver disease (NAFLD), which was induced by a medium fat diet. Methods: Male C57BL/6J mice of 9 weeks old received either (1) a control (C), (2) a calorie restricted (CR), (3) a medium fat (MF; 25%fat) or (4) an intermittent diet (ID), a weekly alternating diet consisting of calorie restriction and medium fat diet ad libitum until sacrifice at the age of 12 months. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11533

16 Samples

Download data: CEL

(Submitter supplied) Analysis of liver gene transcription during feeding of a ketogenic diet. Ketogenic diets may alter physiologic and metabolic profiles in a direction that favors weight loss. C57BL/6J mice were maintained for six weeks on either chow or ketogenic diet. Mice eating KD had lower weights, 90% reduction in insulin levels and increased energy expenditure compared to animals fed chow. Despite consumpiton of a very high fat diet serum lipids remained normal. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2738

Platform:

GPL1261

6 Samples

Download data

Analysis of livers from animals fed a ketogenic diet (KD). KDs, diets that are high in fat and low in carbohydrates, are used as an approach to weight loss. Results provide insight into the KD-induced molecular mechanisms underlying the metabolic state congruous with weight loss.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL1261

Series:

GSE7699

6 Samples

Download data

(Submitter supplied) Diet-induced obesity is the primary determinant of the current epidemic of diabetes. We have explored the role of genetics in this phenomenon, using C57Bl/6 (B6) and 129S6/SvEvTac (129) mice on a low- or high-fat diet. Microarray analysis indicated significant changes in expression levels between B6 and 129 mice in the chromosomal area of Wnt5a and protein kinase C delta (PKC-delta). Thus, caloric efficiency, i.e., the “thrifty gene,” is a dominant-acting genetic determinant of diet-induced obesity in mice and can be linked to a locus on chromosome 14, including genes linked to adipose development and insulin sensitivity.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

45 Samples

Download data: CEL

(Submitter supplied) Overweight is a growing health problem worldwide. The most effective strategy to reduce weight is energy restriction (ER): restriction of food intake without malnutrition. ER has been shown to be beneficial in disease prevention, healthy aging, and inflammation. Recent studies suggest that reducing the protein content of a diet contributes to the beneficial effects by ER. The first objective of our study was to assess the effect of energy restriction on changes in gene expression in adipose tissue. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

44 Samples

Download data: CEL

(Submitter supplied) Sustained caloric restriction (CR) extends lifespan in animal models but the mechanism and primary tissue target(s) have not been identified. Gene expression changes with aging and CR were examined in both heart and subcutaneous white adipose tissue (WAT) of F344 male rats using Affymetrix® RAE 230 arrays and validated by qRT-PCR on 18 genes. In heart, age- associated changes but not CR-associated changes in old. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3102

Platform:

GPL1355

39 Samples

Download data: CEL

Analysis of hearts and white adipose tissues of 28 month old male animals fed a calorie restricted diet since 4 months of age. Sustained caloric restriction (CR) extends lifespan in animal models. Results provide insight into the molecular basis of CR-induced lifespan extension.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 age, 2 growth protocol, 2 tissue sets

Platform:

GPL1355

Series:

GSE6718

39 Samples

Download data: CEL

(Submitter supplied) Dietary restriction (DR) during adulthood can greatly extend lifespan and improve metabolic health in diverse species. However, whether DR in mammals is still effective when applied for the first time at ¬old age remains elusive. Here, we conducted a late-life DR switch experiment employing 800 mice, by switching old animals from ad libitum (AL) to DR and vice versa. Strikingly, the switch from DR-to-AL acutely increased mortality, while the switch from AL-to-DR caused only a weak and gradual increase in survival, highlighting a memory of earlier nutrition. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

48 Samples

Download data: TXT

(Submitter supplied) Dietary methionine restriction (MR) has been shown to increase lifespan and decrease adiposity in rodents. This study was designed to examine the transcriptional effects of MR in metabolically relevant tissues. This experiment contains data from the inguinal white adipose tissue (IWAT).

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL2996

8 Samples

Download data: TXT

(Submitter supplied) Comparison of gene expression of heart (left vent) and diaphragm of normal Sprague Dawley rats, young adult Keywords: Cell type comparison

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3224

Platform:

GPL341

12 Samples

Download data: CEL

Analysis of normal heart left ventricle and diaphragm of young-adult Sprague Dawley males. Concurrent rhythmic contractions of the diaphragm and heart are needed to sustain life. Results provide insight into transcriptional strategies for ensuring long-term energy supplies in these two muscles.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 tissue sets

Platform:

GPL341

Series:

GSE6943

12 Samples

Download data: CEL

(Submitter supplied) During kidney transplantation, ischemia reperfusion injury (IRI) is inevitable and leads to oxidative stress and inflammation. We investigated the role of macronutrients in the effects of dietary restriction on both a phenotypical and transcriptional level, thereby comparing protective and nonprotective diets in search for pathways and regulators involved in the protection against IRI.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11180

36 Samples

Download data: CEL