GEO DataSets

Analysis of peripheral blood leukocytes from tumor-bearing animals for up to 5 days after a single chemotherapeutic treatment of cyclophosphamide (CTX). Results provide insight into the CTX-mediated effects responsible for the antitumor efficacy of chemoimmunotherapy.

Organism:

Mus musculus

Type:

Expression profiling by array, log2 ratio, 2 agent, 4 time sets

Platform:

GPL13209

Series:

GSE27440

30 Samples

Download data: GPR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS4003 GDS4004 GDS4005

Platform:

GPL13209

108 Samples

Download data: GPR

(Submitter supplied) Analysis the effect of cyclophosphamide on splenocytes gene expression. Certain chemotherapeutic drugs such as cyclophosphamide can enhance the antitumor efficacy of immunotherapy because of their capacity to modulate innate and adaptive immunity. Indeed, it has been argued that this capacity may be more significant to chemotherapeutic efficacy in general than is presently appreciated. To gain insights into the core mechanisms of chemoimmunotherapy, we methodically profiled the effects of cyclophosphamide on gene expression in bone marrow, spleen and peripheral blood, and on cytokine expression in plasma and bone marrow of tumor-bearing mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13209

38 Samples

Download data: GPR

(Submitter supplied) Analysis of the effect of cyclophosphamide on peripheral blood leukocyte gene expression. Certain chemotherapeutic drugs such as cyclophosphamide can enhance the antitumor efficacy of immunotherapy because of their capacity to modulate innate and adaptive immunity. Indeed, it has been argued that this capacity may be more significant to chemotherapeutic efficacy in general than is presently appreciated. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13209

30 Samples

Download data: GPR

(Submitter supplied) Analysis the effect of cyclophosphamide on bone marrow gene expression. Certain chemotherapeutic drugs such as cyclophosphamide can enhance the antitumor efficacy of immunotherapy because of their capacity to modulate innate and adaptive immunity. Indeed, it has been argued that this capacity may be more significant to chemotherapeutic efficacy in general than is presently appreciated. To gain insights into the core mechanisms of chemoimmunotherapy, we methodically profiled the effects of cyclophosphamide on gene expression in bone marrow, spleen and peripheral blood, and on cytokine expression in plasma and bone marrow of tumor-bearing mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13209

40 Samples

Download data: GPR

Analysis of spleen (a secondary lymphoid organ) from tumor-bearing animals for up to 5 days after a single chemotherapeutic treatment of cyclophosphamide (CTX). Results provide insight into the CTX-mediated effects responsible for the antitumor efficacy of chemoimmunotherapy.

Organism:

Mus musculus

Type:

Expression profiling by array, log2 ratio, 2 agent, 4 time sets

Platform:

GPL13209

Series:

GSE27440

38 Samples

Download data: GPR

Analysis of bone marrow (a primary lymphoid organ) from tumor-bearing animals for up to 5 days after a single chemotherapeutic treatment of cyclophosphamide (CTX). Results provide insight into the CTX-mediated effects responsible for the antitumor efficacy of chemoimmunotherapy.

Organism:

Mus musculus

Type:

Expression profiling by array, log2 ratio, 2 agent, 4 time sets

Platform:

GPL13209

Series:

GSE27440

40 Samples

Download data: GPR

(Submitter supplied) Certain anticancer drugs, particularly cyclophosphamide (CTX), were shown to enhance the antitumor efficacy of immunotherapy through different immunomodulatory mechanisms. A better understanding of the cellular and molecular basis of CTX-mediated immunomodulation is needed to improve the efficacy of chemoimmunotherapy. Transcript profiling and flow cytometry were used to explore CTX immune-enhancing activity in patients with hematologic malignancies. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15718

33 Samples

Download data: GPR

(Submitter supplied) Purpose: To understand the molecular mechanisms underlying the CTX synergization with antibody therapies in resistant niche-specific organs and BM-resident tumors

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL13112 GPL11154

16 Samples

Download data: TXT