GEO DataSets

Analysis of prefrontal cortices and hippocampi from C57BL/6 adults: APLP2-KO (APLP2-/-) or APPsα-DM (APPα/αAPLP2-/-). Amyloid precursor protein (APP) and AP-like protein 2 (APLP2) play key roles in Alzheimer pathogenesis. Results provide mechanistic insights into APP/APLP2-mediated functions.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 2 tissue sets

Platform:

GPL1261

Series:

GSE27888

12 Samples

Download data: CEL

(Submitter supplied) Despite its key role in Alzheimer pathogenesis, the physiological function(s) of the amyloid precursor protein (APP) and of its proteolytic fragments are still poorly understood. The secreted APPsα ectodomain has been shown to be involved in neuroprotection and synaptic plasticity. The γ-secretase generated APP intracellular domain, AICD, functions as a transcriptional regulator in heterologous reporter assays although its role for endogenous gene regulation has remained controversial. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4134

Platform:

GPL1261

12 Samples

Download data: CEL

(Submitter supplied) The β-amyloid precursor protein APP and the related APLPs, undergo complex proteolytic processing giving rise to several fragments. Whereas it is well established that Aβ accumulation is a central trigger for Alzheimer disease (AD), the physiological role of APP family members and their diverse proteolytic products is still largely unknown. The secreted APPsα ectodomain has been shown to be involved in neuroprotection and synaptic plasticity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4414

Platform:

GPL1261

15 Samples

Download data: CEL

Analysis of prefrontal cortex of adult wild-type, APP knockout, APLP2 knockout, and APPsα knockin (solely expressing the secreted APPsα ectodomain) males. β-amyloid accumulation is a key trigger for Alzheimer's disease. Results provide insight into physiological functions of APP family members.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 4 genotype/variation, 2 strain sets

Platform:

GPL1261

Series:

GSE25926

15 Samples

Download data: CEL

(Submitter supplied) Gene expression analysis of 2-month-old APP/APLP2 double-conditional Knockout (N-dCKO) mice and littermate APLP2 knockout controls, APP knockout and wildtype controls.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

16 Samples

Download data: CEL, CHP