GEO DataSets

Analysis of porcine choroid plexus epithelial cells (PCPEC) infected with virulent Streptococcus suis serotype 2 and isogenic capsular mutant 10cps{delta}EF. The S. suis capsule is critical to its pathogenicity. Results provide insight into choroid plexus cellular response to S. suis meningitis infe

Organism:

Sus scrofa

Type:

Expression profiling by array, count, 3 infection sets

Platform:

GPL3533

Series:

GSE23751

6 Samples

Download data: CEL, CHP

(Submitter supplied) We used microarrays to detail the global gene expression changes following apical infection of porcine choroid plexus epithelial cells (PCPEC) with Streptococcus suis (S. suis)

Organism:

Sus scrofa

Type:

Expression profiling by array

Dataset:

GDS4245

Platform:

GPL3533

6 Samples

Download data: CEL, CHP

(Submitter supplied) We investigated for the first time the in vitro response of PRRSV-infected porcine DCs and monocytes to S. suis. We first assessed the effect of PRRSV infection on the phagocytosis and intracellular survival of S. suis by these two cell populations. We then used a genomic approach to compare the gene expression profiles of both type of cells infected with S. suis, with or without a previous infection with PRRSV.

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16571

32 Samples

Download data: TXT

(Submitter supplied) Streptococcus suis serotype 2 is an important pathogen of pigs, and the disease it causes is characterized by meningitis, septicaemia and pneumonia with high mortality. The pathogen is also an emerging zoonotic agent and threatens humans that are exposed to pigs or their by-products. We investigated the response of PBMC (Peripheral Blood Mononuclear Cell), brain and lung tissues to infection with S. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL3533

18 Samples

Download data: CEL

(Submitter supplied) Swine H1N1 influenza virus and streptococcus suis serotype 2 (SS2) are two important contributors to the porcine respiratory disease complex, which have significant economic impacts. Clinically, swine influenza virus and swine streptococcus suis co-infection is common, which will increase the mortality. However, the pathogenesis of the co-infection remains largely unkown. To explore it, gene expression profiling was to performed to detect comprehensive analysis of the global host response induced by H1N1 virus infection alone, SS2 infection alone, H1N1-SS2 co-infection and PBS control.

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL10162

12 Samples

Download data: TXT

(Submitter supplied) We report the results of gene expression profiling via RNA-sequencing of primary human choroid plexus epithelial cells in vitro that were infected with Borrelia burgdorferi, the causative agent of Lyme disease. Epithelial cells were cultured with B. burgdorferi for 48 hours prior to RNA isolation. Following high-throughput sequencing via Illumina HiSeq 4000, a total of 258 differentially expressed genes were identified. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL20301

6 Samples

Download data: TXT

(Submitter supplied) Streptococcus suis serotype 2 (SS2), a major swine pathogen and an emerging zoonotic agent, has greatly challenged global public health. Systematical information about host immune response to the infection is important for understanding the molecular mechanism of diseases. Here, we investigated the global expression changes in spleen following SS2 infection using the Affymetrix Porcine Genechip. Our findings indicate previously unrecognized gene transcription changes in case of SS infection in vivo. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL3533

9 Samples

Download data: CEL, CHP

(Submitter supplied) We explored the transcriptome change of Streptococcus suis in the presence of ferrous iron and cobalt by RNA sequencing. The data revealed that expression of a lot of genes was altered to respond to ferrous iron and cobalt toxicity. Moreover, most of the genes differentially expressed in response to cobalt are the same as those in response to ferrous iron.

Organism:

Streptococcus suis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28813

9 Samples

Download data: XLSX