GEO DataSets

Analysis of insulinoma cells after short-term (2hr) and long-term (16hr) stimulation with cAMP agonist forskolin. Incretin hormone GLP-1 enhances islet cell survival via cAMP pathway induction in beta cells. Results provide insight into mechanisms by which GLP-1 promotes pancreatic islet viability.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 agent, 2 time sets

Platform:

GPL6247

Series:

GSE31736

4 Samples

Download data: CEL, CHP

(Submitter supplied) Long term exposure to incretin hormones is known to have salutory effects on beta cell function and viability. While short-term cAMP induction is known to have a signature CREB-CRTC target gene response, the long-term effects of cAMP on beta cell gene expression are less well understood. We used rat microarray analysis to compare the genome-wide gene expression response to short-term (2 hours) and long-term (16 hours) stimulations of the cAMP agonist forskolin in INS-1 insulinoma cells.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS4411

Platform:

GPL6247

4 Samples

Download data: CEL, CHP, XLS

(Submitter supplied) Although persistent elevations in circulating glucose concentrations promote compensatory increases in pancreatic islet mass, unremitting insulin resistance causes a deterioration in beta cell function that disrupts glucose balance and signals the progression to diabetes 1. Glucagon like Peptide 1 (GLP1) agonists improve glucose tolerance in insulin resistance, although some individuals are unresponsive to treatment. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19052

8 Samples

Download data: XLSX