GEO DataSets

Analysis of prefrontal/orbito-frontal and parieto-temporal cortex at 17 and 19 gestational weeks. These cortical regions contain presumptive Broca and Wernicke language areas. Results provide insight into molecular mechanisms underlying development of human-specific features of the cerebral cortex.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 development stage, 2 other, 2 tissue sets

Platform:

GPL570

Series:

GSE21858

8 Samples

Download data: CEL

(Submitter supplied) The cerebral cortex underwent a rapid expansion and complexification during recent primate evolution, but the underlying developmental mechanisms remain essentially unknown. In order to uncover genetic networks underlying the development of the human cerebral cortex, we profiled the transcriptome of human fetal cortical domains containing language areas of Broca and Wernicke, as well as associative areas. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4532

Platform:

GPL570

8 Samples

Download data: CEL

(Submitter supplied) Despite the well-established role of the frontal and posterior peri-sylvian cortices in many facets of human-cognitive specializations, including language, little is known about the developmental patterning of these regions in human brain. We performed a genome-wide analysis of human cerebral patterning during mid-gestation, a critical epoch in cortical regionalization. A total of 345 genes were identified as differentially expressed (DE) between superior temporal gyrus (STG) and the remaining cerebral cortex (CTX). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL885 GPL96

25 Samples

Download data: CEL, EXP, TXT

(Submitter supplied) The mammalian neocortex develops layer organizations with regional differences represented by expression of multiple genes at embryonic stages. These genes could play important roles in the formation of areal cyto-architecture, yet, the number of genes identified so far is not sufficient to explain such intricate processes. Here we collected five regions; the medial, dorsal, lateral, rostral, and occipital, from the dissected E16.5 mouse cerebral cortex and performed extensive gene expression analysis using the Affymetrix U74Av2 array. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS615

Platform:

GPL81

12 Samples

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Analysis of medial, dorsal, lateral, rostral, and occipital regions from strain ICR embryo day 16.5 cerebral cortex provides insight into molecular mechanisms of neocortical area and layer formation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 6 tissue sets

Platform:

GPL81

Series:

GSE929

12 Samples

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(Submitter supplied) The signaling pathways orchestrating both the evolution and development of language in the human brain remain unknown. To date, the transcription factor FOXP2 is the only gene implicated in Mendelian forms of human speech and language dysfunction1,2. It has been proposed, that the amino acid composition in the human variant of FOXP2 has undergone accelerated evolution, and this change occurred around the time of language emergence in humans3,4. more...

Organism:

Homo sapiens; Pan troglodytes

Type:

Expression profiling by array

Platforms:

GPL6883 GPL5104

76 Samples

Download data: TXT

(Submitter supplied) Mutations in FOXP2, a member of the forkhead family of transcription factors, are the only known cause of developmental speech and language disorders in humans. To date, there are no known targets of human FOXP2 in the nervous system. The identification of FOXP2 targets in the developing human brain therefore provides a unique tool with which to explore the development of human language and speech. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL5630

8 Samples

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(Submitter supplied) In this study, we map chromatin accessibility and gene expression at single-cell resolution in the developing human cerebral cortex.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platform:

GPL20301

24 Samples

Download data: BED, TSV, TXT

(Submitter supplied) Report of alternative splicing events altered by alcohol exposure in human fetal ceebral cortex in late first trimester.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

4 Samples

Download data: XLSX

(Submitter supplied) We have performed the hybridisation in triplicate using total RNA samples pooled from three independent batches of primary cortical neuron culture derived from E14.5 CD1 mouse brains on one day in vitro (1DIV). We stimulated the cells with 50 ng/ml FGF2 in the presence of 10 μg/ml heparin for 4 hours, and the expression of genes were compared to those in the absence of FGF2. The data were obtained from the three experiments with the best possible conditions and strict measures were applied for the purpose of quality control. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1348

3 Samples

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(Submitter supplied) Tissue was microdissected from 13 regions, including 9 distinct neocortical areas, from both left and right sides of four late second trimester human brain specimens. Gene- and exon-level differential expression analyses were performed by mixed model, nested analysis of variance using the XRAY software from Biotique Systems. Further details available in Johnson, Kawasawa, et al., "Functional and Evolutionary Insights into Human Brain Development through Global Transcriptome Analysis" Neuron, Volume 62, Issue 4, 2009 Keywords: gene- and exon-level analyses

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL5188 GPL5175

190 Samples

Download data: CEL

(Submitter supplied) In the cerebral cortex, projection neurons and interneurons work coordinately to establish functional neural networks and to control the balance between excitatory versus inhibitory synaptic activities for normal cortical functions. While the specific mechanisms that control productions of projection neurons and interneurons are beginning to be revealed, a global characterization of the molecular differences between these two groups of neurons is in need for a more comprehensive understanding of their developmental specifications as well as their cortical functions. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

6 Samples

Download data: TXT

(Submitter supplied) Small non-coding RNAs play important roles in regulating gene expression during development and disease. However, a comprehensive analysis of small RNAs in developing brain is largely lacking. By using next-generation sequencing technique, we carried out a systematic analysis of small RNA transcriptome of rat neocortex from early developmental stage till adult. Our results revealed an extraordinary degree of stage-specific profiling of miRNA, and other classes of small RNAs including snoRNA, rasRNA, scRNA and unexpectedly piRNA, which was considered to be solely expressed in germline tissues. more...

Organism:

Rattus norvegicus

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL13235

18 Samples

Download data: TXT

(Submitter supplied) The demonstration that chromatin exhibits a complex 3 dimensional organization, whereby short and long distance physical interactions correspond to complex gene regulatory processes has opened a new window on understanding the functional organization of the human genome. Recently, chromatin remodeling has also been causally implicated in several neurodevelopmental disorders, including autism and schizophrenia. more...

Organism:

Homo sapiens

Type:

Other

Platform:

GPL11154

6 Samples

Download data: BED, HDF5

(Submitter supplied) K562 cells (duplicate cultures A & B) are treated with 50 micromolar hemin for 0, 6, 12, 24, 48, 72 hours followed by RNA extraction and gene expression profiling on Affymetrix human U133A arrays and analysis by MAS 5.0 Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS826

Platform:

GPL96

12 Samples

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Expression profiling of K562 erythroleukemia cells induced to differentiate into erythroid-like cells by hemin. K562 cells examined at various time points up to 72 hours following treatment with 50 uM hemin. Results provide insight into mechanisms underlying hemoglobinization.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 6 time sets

Platform:

GPL96

Series:

GSE1036

12 Samples

Download data

(Submitter supplied) Bergmann glial cells of the vertebrate cerebellum play essential roles in the development and maintenance of cerebellar structure and function. During development, Bergmann glia provide structural support to the expanding cerebellar anlage and also serve as guides for migrating neurons (granule cells). As the cerebellum matures, Bergmann glia become important in dendritic arborization, synapse maintenance and synaptic function. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

10 Samples

Download data: CEL

(Submitter supplied) Fetal life is a crucial period for sexual reproduction when bipotential gonads differentiate into either a testis or an ovary. Gaining insights into the complex molecular events underlying this process is central to a better understanding of disorders of sexual development. The present work therefore intends to improve the knowledge on molecular pathways at play during gonad development in humans using RNA-Sequencing.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

48 Samples

Download data: BED, GTF, TXT, XLSX

(Submitter supplied) We compared the genome-wide patterns of DNA methylation in the brains of humans to those of our closest evolutionary relative, chimpanzees, using base-pair resolution whole-genome methylation maps of the prefrontal cortex. Our data reveal that the prefrontal cortex is the most heavily methylated among the human tissues examined so far. Nevertheless, hundreds of genes exhibit dramatically reduced levels of promoter DNA methylation in the human brain relative to the chimpanzee brain. more...

Organism:

Pan troglodytes; Homo sapiens

Type:

Methylation profiling by high throughput sequencing

Platforms:

GPL15434 GPL9115 GPL15433

6 Samples

Download data: GFF

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Macaca mulatta; Homo sapiens; Pan troglodytes

Type:

Expression profiling by array; Expression profiling by high throughput sequencing

5 related Platforms

92 Samples

Download data: CEL, TXT