Similar studies for GEO DataSets (Select 4841) - GEO DataSets

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Items: 16

Select item 48411.

Analysis of pathological skeletal muscle fibers from patients with dermatomyositis (DM), polymyositis (PM), or inclusion body myositis (IBM). Results provide insight into the molecular mechanisms underlying the pathogenesis of DM, PM, and IBM.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 4 disease state sets

Platform:: GPL6244
Series:: GSE48280
19 Samples

Download data: CEL

DataSet

Accession:: GDS4841

ID:: 4841

Select item 2000482802.

Expression data from inflammatory myopathies

(Submitter supplied) MHC-I overexpression in muscle biopsies is a hallmark of inflammatory myopathies.However the mechanisms of MHC-I overexpression in each disease is not well understood. Microarray analysis from MHC-I-microdissected myofibers showed a differential expression signature in each inflammatory myopathy. Innate immunity and IFN-I pathways are upregulated vs healthy controls, specifically in dermatomyositis (DM).

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4841
Platform:: GPL6244
19 Samples

Download data: CEL

Series

Accession:: GSE48280

ID:: 200048280

Select item 2000835583.

Purified CD123+BDCA4+ plasmacytoid dendritic sorted cell-population derived from IFN signature positive primary Sjögren’s syndrome patients and IFN signature negative primary Sjögren’s syndrome patients compared to Healthy Control individuals

(Submitter supplied) The IFN type I signature is present in over half of primary Sjögren’s syndrome (pSS) patients and associated with higher disease-activity and autoantibody presence. Plasmacytoid dendritic cells (pDCs) are considered to be the source of enhanced IFN type I expression. The objective of this study was to unravel the molecular pathways underlying IFN type I bioactivity in pDCs of pSS patients. We used microarray gene expression analysis to detail the programme of gene expression underlying IFN type I bioactivity in pDCs of primary Sjogrens' Syndrome patients.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
7 Samples

Download data: CEL

Series

Accession:: GSE83558

ID:: 200083558

Select item 2000015514.

dermatomyositis

(Submitter supplied) muscle biopsies of normal and dermatomyositis patients Keywords: other

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
23 Samples

Download data

Series

Accession:: GSE1551

ID:: 200001551

Select item 2001283145.

Dermatomyositis skin transcriptomic signature

(Submitter supplied) Dermatomyositis is a cutaneous and muscular auto-immune condition associated with specific autoantibodies. MDA5 antibody-associated DM has higher mortality. We demonstrate here for the first time using skin microarray analysis that MDA5+ DM is associated with a greater type I interferon skin signature than MDA5- DM, mainly involving the IFN- κ member produced by skin keratinocytes

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17586
13 Samples

Download data: CEL

Series

Accession:: GSE128314

ID:: 200128314

Select item 2000002816.

Inflammatory myopathy

(Submitter supplied) Molecular profiles of muscle tissue in patients with inflammatory myopathies Keywords: other

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS198
Platform:: GPL91
12 Samples

Download data

Series

Accession:: GSE281

ID:: 200000281

Select item 1987.

Inflammatory myopathy

Molecular profiles of muscle tissue in patients with inflammatory myopathies.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 12 specimen sets

Platform:: GPL91
Series:: GSE281
12 Samples

Download data

DataSet

Accession:: GDS198

ID:: 198

Select item 2001049448.

Region-specific Innate Antiviral Responses of the Human Epididymis

(Submitter supplied) Viral infections of the epididymis are associated with epididymitis, which damages the epithelium and impairs fertility. We showed previously that innate immune response genes were differentially expressed in the corpus and cauda region of the human epididymis in comparison to the caput. Here we investigate the antiviral defense response mechanisms of human epididymis epithelial (HEE) cells. Toll-like receptor (TLR) 3 and retinoic acid-inducible gene I (RIG-I)- like receptors (RLRs) are enriched in HEE cells from the corpus and cauda region. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
6 Samples

Download data: DIFF

Series

Accession:: GSE104944

ID:: 200104944

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000004939.

Gene expression profiling in DQA1*0501+ children with untreated dermatomyositis

(Submitter supplied) Juvenile dermatomyositis (JDM), the most common pediatric inflammatory myopathy, is a systemic vasculopathy affecting young children. Epidemiology studies documenting an antecedent illness in the 3 mo before the first definite symptom (rash and/or weakness) of JDM are supported by immunologic data that suggest that the disease pathophysiology is Ag driven. The purpose of this study was to compare the gene expression profiles in muscle biopsies of four untreated DQA1*0501(+) JDM children with profiles from children with a known necrotizing myopathy (Duchenne muscular dystrophy), as well as an in vitro antiviral model (NF90), and healthy pediatric controls. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Datasets:: GDS215 GDS258
Platforms:: GPL246 GPL80
14 Samples

Download data: CEL

Series

Accession:: GSE493

ID:: 200000493

Select item 25810.

Juvenile dermatomyositis muscle profile (HuGeneFL)

Examination of skeletal muscle from juvenile dermatomyositis (JDM) patients, a common pediatric inflammatory myopathy. Muscle biopsies processed singly or in mixed groups of two. Patients genotyped for TNFalpha which is associated with prolonged disease.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 8 specimen sets

Platform:: GPL80
Series:: GSE493
10 Samples

Download data: CEL

DataSet

Accession:: GDS258

ID:: 258

Select item 21511.

Juvenile dermatomyositis muscle profile (MuscleChip)

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 specimen sets

Platform:: GPL246
Series:: GSE493
4 Samples

Download data: CEL

DataSet

Accession:: GDS215

ID:: 215

Select item 20012597712.

MicroRNA and mRNA profiling in the idiopathic inflammatory myopathies

(Submitter supplied) Objectives: The idiopathic inflammatory myopathies (IIMs) are heterogeneous autoimmune conditions of skeletal muscle inflammation and weakness. MicroRNAs (miRNAs) are short, non-coding RNA which regulate gene expression of target mRNAs. The aim of this study was to profile miRNA and mRNA in IIM and identify miRNA-mRNA relationships which may be relevant to disease. Materials and methods: mRNA and miRNA in whole blood samples from 7 polymyositis (PM), 7 dermatomyositis (DM), 5 inclusion body myositis (IBM) and 5 non-myositis controls was profiled using next generation RNA sequencing. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL20301
48 Samples

Download data: XLS

Series

Accession:: GSE125977

ID:: 200125977

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20004038713.

Liposome transfection of miR-145 induces immune response via RIG-I in mesenchymal stem cells

(Submitter supplied) Liposomal transfection reagents are frequenly used in gene deliverytransfer experiments. The validity of these experiments depends on the absence of changes in genes other than the target gene. Here we report that transfection of synthetic microRNA-145 using liposomes, but not electroporation, induced the upregulation of a range of immune-related genes in human mesenchymal stem cells. The immune response was dependent on the binding of microRNA-145 to retinoic acid inducible gene-I, and was independent on endosome functionality and toll-like receptors. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
12 Samples

Download data: TXT

Series

Accession:: GSE40387

ID:: 200040387

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001197114.

Skeletal muscles of untreated children with juvenile dermatomyositis

(Submitter supplied) Background :To evaluate the impact of the duration of chronic inflammation on gene expression in skeletal muscle biopsies (MBx) from untreated children with juvenile dermatomyositis (JDM) and identify genes and biological processes associated with the disease progression, expression profiling data from 16 girls with active symptoms of JDM greater or equal to 2 months were compared with 3 girls with active symptoms less than 2 months. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3417
Platform:: GPL96
23 Samples

Download data: CEL, CHP

Series

Accession:: GSE11971

ID:: 200011971

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 341715.

Untreated juvenile dermatomyositis muscle biopsies

Analysis of skeletal muscle biopsies from untreated girls with active symptoms of juvenile dermatomyositis (JDM) less than 2 months or greater than 2 months. Results provide insight into the impact of the duration of chronic inflammation on gene expression in muscle of untreated children with JDM.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 disease state sets

Platform:: GPL96
Series:: GSE11971
23 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3417

ID:: 3417

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20003224516.

Fiorentino 2006-7 dermatomyositis, lupus, control skin

(Submitter supplied) Background: Dermatomyositis (DM) is an autoimmune disease that mainly affects the skin, muscle, and lung. The pathogenesis of skin inflammation in DM is not well understood. Methodology and Findings: We analyzed genome-wide expression data in DM skin and compared them to those from healthy controls. We observed a robust upregulation of interferon (IFN)-inducible genes in DM skin, as well as several other gene modules pertaining to inflammation, complement activation, and epidermal activation and differentiation. more...