GEO DataSets

Analysis of dendritic cells for up to 24 hours following infection with Leishmania major. Leishmaniasis is a group of insect vector transmitted parasitic diseases. Results provide insight into the molecular response of dendritic cells to L. major infections.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 infection, 4 time sets

Platform:

GPL570

Series:

GSE42088

15 Samples

Download data: CEL

(Submitter supplied) Leishmania major infected human dendritic cells (DCs) exhibit a marked induction of IL-12 ultimately promoting a robust Th1-mediated response associated with parasite killing and protective immunity. In this study, we utilized Affymetrix Genechips to globally assess the host cell genes and pathways associated with L. major infection during early infection (2, 4, 8, and 24 hrs) in human myeloid-derived DCs. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5086

Platform:

GPL570

15 Samples

Download data: CEL, TXT

(Submitter supplied) Monocyte derived dendritic cells (MDDC) were infected with Leishmania major or Leishmania donovani parasites and collected at 4, 8, and 24 hours post-infection to analyze the differential effects those parasite species have on human host cell gene expression over time.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16025

35 Samples

Download data: PAIR

(Submitter supplied) Monocyte derived dendritic cells (MDDC) were infected with Leishmania major parasites which were knockout mutants of either lpg1 or lpg2 genes that responsible for expression of surface molecular structures on the parasites in order to assess the effects those molecules have on human host cell gene expression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16025

24 Samples

Download data: PAIR

(Submitter supplied) The ability of dendritic cells (DCs) to activate immunity is linked to their maturation status. In prior studies we have shown that selective antibody-mediated blockade of inhibitory FcgRIIB receptor on human DCs in the presence of activating immunoglobulin (Ig) ligands leads to DC maturation and enhanced immunity to antibody-coated tumor cells. Here we show that Fcg receptor (FcgR) mediated activation of human monocytes and monocyte-derived DCs is associated with a distinct gene expression pattern, including several inflammation associated chemokines as well as type 1 interferon (IFN) response genes including the activation of signal transducer and activator of transcription 1 (STAT1). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

26 Samples

Download data: CEL, CHP