GEO DataSets

Analysis of Mus spretus livers from the polluted Domingo Rubio stream. Results provide insight into the biological effects of an industrial settlement on the liver of an aboriginal species.

Organism:

Mus musculus; Mus spretus

Type:

Expression profiling by array, count, 5 other sets

Platform:

GPL4134

Series:

GSE33663

19 Samples

Download data: TXT

(Submitter supplied) We evaluated the suitability of high-throughput transcriptomics approach to monitor terrestrial ecosystems. Free-living Mus spretus from several polluted sites of Huelva (Andalusia, SW Spain) were compared with mice from Doñana Biological Reserve (“Santa Olalla” lagoon (SOL) used as negative control). As most popular bioindicators, M. spretus is poorly represented in gene databases, therefore limiting the use of genomics in ecotoxicological studies. more...

Organism:

Mus spretus; Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5331

Platform:

GPL4134

19 Samples

Download data: TXT

(Submitter supplied) This study investigates transcriptomic responses of Atlantic salmon lice, Lepeophtheirus salmonis exposed to cypermethrin, a commonly used antiparasitic agent used in aquaculture. Copepodid L. salmonis were exposed to cypermethrin (Betamax®) at a concentration of 1.0ppb

Organism:

Lepeophtheirus salmonis

Type:

Expression profiling by array

Platform:

GPL15566

12 Samples

Download data: TXT

(Submitter supplied) Microarray analysis to examine the relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (CPR) null mice. Keywords: ordered

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1093

Platform:

GPL81

4 Samples

Download data

Analysis of liver from male 3 month old hepatic NADH-cytochrome P450 reductase null mutants (POR). Results provide insight into the central role of POR and the P450 system in controlling hepatic homeostasis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL81

Series:

GSE1468

4 Samples

Download data

(Submitter supplied) In this study we obtained gene expression profiles of MCFS and parental MCF7 cell lines using Illumina microarrays

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6883

6 Samples

Download data: TXT

(Submitter supplied) One of the top priorities of the swine industry worldwide is to decrease the susceptibility of its animals to infectious diseases. There is therefore now an increased focus on the production of more “robust” animals, which have lower susceptibility to a broad range of infectious diseases. One general measure of immune competence is the proliferative response of peripheral blood mononuclear cells (PBMC) to mitogenic stimulation. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL14897

24 Samples

Download data: GPR

(Submitter supplied) For decades, formalin-fixing and paraffin embedding (FFPE) has been routinely used to preserve tissue samples for histological analysis. Global gene expression analysis of these archival tissues has the potential to greatly advance research attempting to link perturbations in molecular pathways to disease outcome. We investigated 16-year-old FFPE mouse liver samples treated with phenobarbital and created a protocol for their analysis using Agilent gene expression arrays. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13912

28 Samples

Download data: TXT

(Submitter supplied) To investigated the molecular distinction and functional correlation among different histopathological types of gastric neoplasia, the whole genome expression profiling of gastric early-stage carcinoma(EGC) and high-grade and low-grade intraepithelial neoplasia (HGIN and LGIN) were explored. This research will provide biological evidence for the clinical application in different gastric early-stage neoplasia.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

77 Samples

Download data: TXT

(Submitter supplied) In this study, RNA-Seq technology was adopted to investigate the differences in expression profiles of the hepatic lipid metabolism-related genes and the associated pathways between juvenile and laying hens. RNA-Seq analysis was carried out to estimate total RNA harvested from the liver of juvenile hens (n = 3) and laying hens (n = 3). Compared with juvenile hens, 2574 differentially expressed (DE) genes (1487 down and 1087 up) with P ≤ 0.05 were obtained, and 955 of these genes were significantly DE (SDE) at a false discovery rate (FDR) of 0.05 and fold-change ≥ 2 in laying hens. more...

Organism:

Gallus gallus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19005

6 Samples

Download data: TXT

(Submitter supplied) Rat Retinal Müller cells from diabetic rats (diabetes duration 6 months) compared to Rat Retinal Müller cells from healthy rats. Diabetes was induced by streptozotozine. Diabetic rats were treated with small doses of insulin to prevent catabolism. Keywords: ordered

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

5 Samples

Download data: CEL, EXP

(Submitter supplied) E12.5 mouse whole embryo, E12.5 placenta, embryonic stem (ES) cells, and trophoblast stem (TS) cells were compared on a novel microarray design to validate the system. The in situ-synthesized 60-mer oligonucleotide microarray platform contains approximately 44,000 DNA features, and was designed to detect transcripts from all known genes, as well as about 5,000 potential genes, as identified by the NIA Mouse Gene Index 2.0. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2552

12 Samples

Download data: TIFF, TXT

(Submitter supplied) E12.5 mouse whole embryo and E12.5 placenta total RNA were pooled to create 25:75, 50:50, and 75:25 ratio mixtures, based on Bioanalyzer quantitation. These samples, along with the original unmixed RNAs, were used as templates for duplicate linear amplification labeling reactions. cRNA target mixtures were hybridized against a Universal Mouse Reference (Stratagene). Pairwise comparison using the NIA Microarray Analysis (ANOVA) software produced log ratios, which were compared to the expected log ratios for genes showing statistically significant (FDR<0.05) differential expression between unmixed embryo and placenta. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2549

10 Samples

Download data: TIFF, TXT

(Submitter supplied) The objective of the experiment is to determine the genes differentially expressed in the adrenal gland of adult (12-week) BPH and BPL mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3777

Platform:

GPL81

6 Samples

Download data: CEL, CHP

(Submitter supplied) We performed Affymetrix MG-U74Av2 GeneChip experiements on mRNA from the adrenal glands of the BPH hypertensive and BPL hypotensive mouse strains. All mice were aged-matched at 5 weeks. We obtained the mice from Jackson Laboratories, Bar Harbor, ME. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1011

Platform:

GPL81

6 Samples

Download data: CEL, EXP

Analysis of adrenal glands from genetically/hereditary hypertensive (BPH/2) and genetically/hereditary low-blood pressure (BPL/1) 12-week old adults. Results provide insight into molecular mechanisms underlying the pathogenesis of genetic hypertension.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL81

Series:

GSE19342

6 Samples

Download data: CEL, CHP

Expression profiling of adrenal glands from blood pressure high (BPH) males at the prehypertensive stage. BPH males examined at 5 weeks of age. Results compared to gene expression in SHR rat model, and provides insight into mechanisms of hypertension shared across species.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 disease state, 2 strain sets

Platform:

GPL81

Series:

GSE1674

6 Samples

Download data: CEL, EXP