GEO DataSets

Analysis of ovarian adenocarcinoma cell lines HEY, OVCAR5 and UCI-101 treated 24h with NSAIDs diclofenac or indomethacin (300mM). NSAID drugs associated with a reduced risk of various cancers. Results provide insight into molecular pathways mediating effects of NSAID treatment in ovarian cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 agent, 3 cell line sets

Platform:

GPL6104

Series:

GSE45052

9 Samples

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(Submitter supplied) Epidemiological studies have shown that the regular use of non-steroidal anti-inflammatory (NSAIDs) drugs is associated with a reduced risk of various cancers. In addition, in vitro and experiments in mouse models have demonstrated that NSAIDs decrease tumor initiation and/or progression of several cancers. However, there are limited preclinical studies investigating the effects of NSAIDs in ovarian cancer. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5353

Platform:

GPL6104

9 Samples

Download data: TXT

(Submitter supplied) Purpose: dose response analysis of E2F1 target genes expression in flow-sorted fractions with increasing amounts of fluorescently labled E2F1 Methods:U2OS pTRIPZ-YFP-ER-E2F1 cells were grown in full serum-containing growth medium and treated with 500 ng/ml doxycycline for 48 hours followed by addition of 90 nM OHT for an additional 20 hours. Cells from different YFP fractions were sorted by flow cytometry. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20301

5 Samples

Download data: TXT

(Submitter supplied) Xenograft ovarian tumors are useful model to test therapeutic candidates in vivo. We used microarrays to gain insight into the expression changes during tumor growth and induced by the vitamin D analog, MT19C at multiple time points.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3872

Platform:

GPL6244

15 Samples

Download data: CEL

Analysis of ovarian xenograft tumors from nude mice inoculated with SKOV-3 cells then treated with anti-cancer agent MT19c. Xenograft tumors collected up to 30 days after initiation of MT19c treatment. Results provide insight into molecular mechanisms underlying ovarian xenograft tumor progression.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 3 time sets

Platform:

GPL6244

Series:

GSE23616

15 Samples

Download data: CEL

(Submitter supplied) We examined the transcriptional changes modulated by ESR2 agonist liquiritigenin by perfroming global transcriptome analysis. ES2 cells were treated with either vehicle or liquiritigenin for 24 h and the isolated RNA was utilized for RNA-seq analysis. Our results demonstrated that liquiritigenin modulated several genes that are involved in NF-kB signaling, inflammation, NRF2 mediated oxidative stress response, and MMP signaling.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21290

4 Samples

Download data: TXT