GEO DataSets

Analysis of stimulated CD4+ T cells (derived from buffy coat PBMCs) treated with edelfosine at 3.3µg/ml. Edelfosine is a cytotoxic drug taken up by highly proliferating cells such as activated immune cells. Results provide insight into the molecular basis of edelfosine action in immune T cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 2 protocol sets

Platform:

GPL6244

Series:

GSE44392

12 Samples

Download data: CEL

(Submitter supplied) The cytotoxic drug edelfosine is a synthetic analog of 2-lysophosphatidylcholine. Edelfosine is incorporated by highly proliferating cells, e.g. activated immune cells. It is unknown if the described mechanisms for edelfosine action attained by in vitro approaches exclusively contribute to the observed EAE-amelioration or if edelfosine may exert additional, probably more general and possibly immunoablative effects within the setting of autoimmunity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS5304 GDS5544

Platform:

GPL6244

20 Samples

Download data: CEL

Analysis of unstimulated CD4+ T cells (derived from buffy coat PBMCs) treated with edelfosine at 3.3 or 10 µg/ml. Edelfosine is a cytotoxic drug taken up by highly proliferating cells such as activated immune cells. Results provide insight into molecular basis of edelfosine action in immune Tcells.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 3 dose sets

Platform:

GPL6244

Series:

GSE44392

12 Samples

Download data: CEL

(Submitter supplied) We isolated CD4+ T cells from draining lymph nodes 7 days post EAE from DA rats treated with vitamin D supplemented, vitamin D deprived or regular diet

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6247

17 Samples

Download data: CEL, CHP

(Submitter supplied) This study demonstrates quantitative and qualitative differences between type I IFN signatures in autoimmunity and viral infection using purified CD4pos T cells and CD16pos- and CD16neg-monocyte subsets. We were able to discriminate between cell-specific viral response signatures and the pathogenically amplified IFN signatures observed in autoimmunity. The differences were of both a qualitative and quantitative nature, as the signatures in the patients with SLE were characterized by much more complexly compiled gene patterns with increased absolute gene expression levels.

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS4888 GDS4889 GDS4890

Platform:

GPL570

36 Samples

Download data: CEL, CHP

Analysis of CD16+ monocytes from SLE patients and YFV-immunized healthy donors. The YFV immunization can be regarded as a real viral infection, based on clinical/serological manifestations. Results provide insight into differences in type I interferon responses in autoimmunity and viral infection.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 7 individual, 3 protocol sets

Platform:

GPL570

Series:

GSE51997

10 Samples

Download data: CEL, CHP

Analysis of CD16- monocytes from SLE patients and YFV-immunized healthy donors. The YFV immunization can be regarded as a real viral infection, based on clinical/serological manifestations. Results provide insight into differences in type I interferon responses in autoimmunity and viral infection.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 8 individual, 3 protocol sets

Platform:

GPL570

Series:

GSE51997

12 Samples

Download data: CEL, CHP

Analysis of CD4+ T cells from SLE patients and YFV-immunized healthy donors. The YFV immunization can be regarded as a real viral infection, based on clinical/serological manifestations. Results provide insight into differences in type I interferon responses in autoimmunity and viral infection.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 10 individual, 3 protocol sets

Platform:

GPL570

Series:

GSE51997

14 Samples

Download data: CEL, CHP

(Submitter supplied) New alkyl-phospholipids (APLs) that are structurally derived from the platelet-activating factor are promising candidates for anticancer treatment. After the incorporation into cell membranes, APLs are able to interfere with a wide variety of key enzymes implicated in cell growth, motility, invasion and apoptosis. Besides the prototype edelfosine, we presented a novel group of APLs, glycosidated phospholipids that efficiently inhibit cell proliferation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3796

Platform:

GPL6480

12 Samples

Download data: TXT

Analysis of HaCaT keratinocytes treated with alkylphospholipids (APLs) Ino-C2-PAF, Glc-PAF, and edelfosine. APLs interfere with a variety of key enzymes implicated in cell growth, motility, invasion, and apoptosis. Results provide insight into mechanism of action of APLs.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 agent sets

Platform:

GPL6480

Series:

GSE20722

12 Samples

Download data: TXT

(Submitter supplied) Purpose: To elucidate the potential immune-regulatory mechanism of TRAIL of activated T cells in EAE, we analyzed gene expression profiles of splenic CD4+ T cells from EAE mice treated with TRAIL by RNA sequencing and transcriptome analysis. Methods: Splenic CD4+ T cell mRNA profiles of control or EAE mice treated with vehicle or TRAIL were generated by deep sequencing using Illumina Solexa. Library construction of all samples were used by Agilent's SureSelect Strand Specific RNA Library Preparation Kit for 75SE (Single-End or Paired-End) sequencing on Solexa platform. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

3 Samples

Download data: TSV, XLSX