GEO DataSets

Analysis of thyroid from normal BALB/c adults 24 hours after injection in the tail vein with 13, 130, or 260 kBq of radioactive iodine (131I). The absorbed doses to thyroid were 0.85, 8.5, or 17 Gy. Results provide insight into dose-specific molecular responses of thyroid after 131I administration.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 dose sets

Platform:

GPL6885

Series:

GSE54594

4 Samples

Download data

(Submitter supplied) Transcriptomic profiling of normal mouse thyroid tissue following 211At irradiation Introduction The cellular response to stimuli can be studied on different molecular levels, including gene expression regulation. RNA microarray is a high-throughput technique that enables comparison of genome-wide transcriptional status between samples. 211At-labeled radiopharmaceuticals are potentially useful for tumor therapy. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

24 Samples

Download data: TXT

(Submitter supplied) Transcriptomic profiling of normal mouse thyroid tissue following 131At irradiation In the present investigation, microarray analysis was used to monitor transcriptional activity in thyroids in mice 24 h after 131I exposure. The aims of this study were to 1) assess the transcriptional patterns associated with 131I exposure in normal mouse thyroid tissue and 2) identify novel biomarkers for 131I exposure. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5803

Platform:

GPL6885

4 Samples

Download data: TXT

(Submitter supplied) Transcriptomic profiling of normal mouse thyroid tissue following 211At irradiation Astatine-211 (211At) is an alpha particle emitting halogen with almost optimal linear energy transfer (LET) for creating DNA double strand breaks, and is thus proposed for radionuclide therapy when bound to tumor-seeking agents. Un-bound 211At accumulates in the thyroid gland. The concept of basal radiation-induced biological effects in thyroid tissue is to a high degree unknown and is most valuable. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

18 Samples

Download data: TXT

(Submitter supplied) Transcriptomic profiling of normal mouse lung, liver, kidney, and spleen tissue following 211At irradiation.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

90 Samples

Download data: IDAT, SDF, TXT

(Submitter supplied) Introduction Iodine-131 (131I) is frequently used in nuclear medicine. Unbound or released 131I accumulate in the thyroid gland and may be detrimental to normal thyroid function. The aim of the present study was to identify biomarkers for 131I exposure in rat thyroid tissue and to assess the effect on thyroid function. Methods Thirty six male Sprague Dawley rats were i.v. injected with 150 µl saline solution containing 9.0, 88, 170, 260, 340, 760, 1300, or 4700 kBq (group A-H) 131I, or mock-treated with 150 µl saline solution only, and killed at 24 h after injection. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL15084

36 Samples

Download data: TXT

(Submitter supplied) Transcriptomic profiling of normal mouse kidney cortex and medulla following 177Lu irradiation

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

72 Samples

Download data: TXT

(Submitter supplied) Circadian rhythm study on transcriptional responses to i.v. administered 90 kBq iodine-131 after 24h in mouse kidney cortex and medulla, liver, lungs, spleen, and thyroid. Female BALB/c nude mice (n=4/group) were i.v. injected with 90 kBq 131I at three different times of day, i.e. at 9.00 am, at 12.00 pm, or at 3.00 pm, and killed under anesthesia after 24h following treatment for excision of organs. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

136 Samples

Download data: TXT

(Submitter supplied) RNA microarray analysis of low-dose and dose rate responses versus time after i.v. administration of 211At. Female BALB/c nude mice were intravenously injected with 1.7 kBq 211At and killed after 1 h, 6 h, or 7 d, or injected with 105 or 7.5 kBq and killed after 1 h and 6 h, respectively. Controls were mock-treated. Kidneys, liver, lungs, and spleen were excised, flash-frozen, and stored at -80°C. Total RNA was extracted and subjected to expression analysis using RNA microarray technology. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

80 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of rat thyroid cells comparing control untreated thyroid cells with 131I irradiated thyroid cells. Goal was to invesigate radiation induced gene expression profiles

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL14797

49 Samples

Download data: TXT

(Submitter supplied) Transcriptomic profiling of normal mouse tissue and blood following 177Lu irradiation

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

108 Samples

Download data: TXT

(Submitter supplied) Time series for gene expression changes following 3 Gy and 10 Gy of ionizing radiation exposure. Keywords: time-course

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS479

Platform:

GPL91

12 Samples

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Temporal analysis of effect of 3 Gy and 10 Gy ionizing radiation (IR) exposure on lymphoblastoid cells. Various time points up to 24 hours examined.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 dose, 2 stress, 6 time sets

Platform:

GPL91

Series:

GSE701

12 Samples

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(Submitter supplied) Radiation is an established cause of thyroid cancer and growing evidence supports a role for H2O2 in spontaneous thyroid carcinogenesis. Little is known about the molecular programs activated by these agents in thyroid cells. We profiled the DNA damage response and cell death induced by γ-radiation (0.1–5Gy) and H2O2 (0.0025–0.3mM) in primary human thyroid cells and T-cells. While the two cell types had more comparable radiation responses, 3- to 10-fold more H2O2 was needed to induce detectable DNA damage in thyrocytes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

64 Samples

Download data: CEL

(Submitter supplied) Intraoperative radiotherapy (IOERT) is a high radiation therapeutic technique which administers a single high dose of ionizing radiation (IR) immediately after surgical tumor removal in order to destroy the residual cancer cells in the site at high risk for recurrence. IR is able to regulate several genes and factors involved in cell-cycle progression, survival and/or cell death, DNA repair and inflammation modulating an intracellular response radiation dependent producing an imbalance in cell fate decision. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

12 Samples

Download data: TXT

(Submitter supplied) Background: The effects of dose-rate and its implications on radiation biodosimetry methods are not well studied in the context of large-scale radiological scenarios. There are significant health risks to individuals exposed to an acute dose in such an event, but the most realistic scenario would be a combination of exposure to both high and low dose-rates, from both external and internal radioactivity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13497

35 Samples

Download data: TXT

(Submitter supplied) Rationale: Auger electrons bear a low energy (0-10 keV) which is deposited in a very small volume (a few nm3) around the site of emission. From a radio-toxicological point of view, the effects of Auger electrons on normal tissues are largely unknown, understudied and generally assumed negligible. In this context, the discovery that the Auger electron emitter 99mTc can induce stunning on primary thyrocytes in vitro, at low doses, is intriguing. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13912

8 Samples

Download data: TXT

(Submitter supplied) Female BALB/c nude mice (n=3/group) were subjected to partial body irradiation under anesthesia using 2 Gy external photon (4 MV, nominal) irradiation. In group A, the collum (i.e. the thyroid) was irradiated; in group B, thorax+abdomen were irradiated, and in group C, collum+thorax+abdomen were irradiated. The control group (n=5) was anesthetized but not irradiated. At 24 h after treatment, the kidneys, liver, lungs, spleen, and thyroid were excised, flash-frozen, and stored at -80°C. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

88 Samples

Download data: TXT

(Submitter supplied) Characterization of biological and chemical responses to ionizing radiation by various organisms is essential for potential applications in bioremediation, alternative modes of detecting nuclear material, and national security. Escherichia coli DH10β is an optimal system to study the microbial response to low-dose ionizing radiation at the transcriptional level because it is a well-characterized model bacterium and its responses to other environmental stressors, including those to higher radiation doses, have been elucidated in prior studies. more...

Organism:

Escherichia coli

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28126

30 Samples

Download data: TXT

(Submitter supplied) This study investigates three radiation exposure scenarios in BALB/c and C57BL/6 mice: (1) low dose (LD) group -- four weekly doses of 7.5 cGy, (2) high dose (HD) group -- four weekly doses of 1.8 Gy, (3) unexposed group -- four weekly sham exposures. We then used comparative expression profiles of the mouse mammary gland and cardiac blood to build a model of candidate tissue functions associated with LD cancer susceptibility in these strains and murine and human knowledgebases to characterize these tissue functions and their relevance to breast cancer.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4323

Platform:

GPL8759

51 Samples

Download data: CEL