GEO DataSets

Gene expression in lungs of males 15 and 40 days post-infection with Seoul hantavirus compared with females. Part of an investigation into whether sex steroid hormones modulate sex differences in host immune response.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 gender, 3 infection sets

Platform:

GPL85

Series:

GSE488

12 Samples

Download data: CEL

(Submitter supplied) In the field, adult male rodents are more frequently infected with hantaviruses than females. Early data suggests that sex steroid hormones modulate sex differences in host immune response. This project focuses on elucidating sex differences in gene expression in the lungs of infected males 15 and 40 days post infection with Seoul virus (naturally occurring hantavirus in Norway rats) relative to infected females 15 and 40 days post infection on 12 RG_U34 GeneChips. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS62

Platform:

GPL85

12 Samples

Download data: CEL

(Submitter supplied) Gene expression profiles were examined in whole lung tissue collected from male and female Long-Evans rats at different time points after inoculation with Seoul virus (i.e., the species-specific hantavirus that infects Norway rats) We used microarray analyses to analyze global gene expression differences between the sexes during hantavirus infection Keywords: time course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3050

Platform:

GPL341

24 Samples

Download data: CEL

Analysis of male and female lungs at various time points up to 40 days post-infection with Seoul hantavirus. Males and females differ in their susceptibility to several RNA and DNA viruses. Results provide insight into the influence of gender in the response to Seoul hantavirus infections.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 gender, 2 infection, 4 time sets

Platform:

GPL341

Series:

GSE7271

24 Samples

Download data: CEL

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) To understand the host transcriptional response to S. enterica serovar Choleraesuis (S. Choleraesuis), the first generation Affymetrix porcine GeneChip® was used to identify differentially expressed genes in the mesenteric lymph nodes responding to infection at acute (8 hours (h), 24h, 48h post-inoculation (pi)) and chronic stages (21 days (d) pi) The objectives of this study were to identify and examine the stereotypical gene expression response within the host mesenteric lymph nodes to S. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL3533

15 Samples

Download data: CEL, EXP

(Submitter supplied) Gender dependent gene expression in the kidney of 36 day old rats using the Affymetrix GeneChip rat expression set 230 array RAE230A. mixed model ANOVA using log2 transformed signal intensity of PM. Keywords: repeat

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL3240

18 Samples

Download data: CEL

(Submitter supplied) The in-house microarray consists of 167 RT-PCR derived DNA fragments representing 167 ORFs from bovine. The DNA fragments are printed 4 times on the surface of the microarray (four-replicate blocks). The 167 immune and endocrine genes grouped into the following categories: cytokine genes, chemoattractants or chemokines and their respective receptor genes, immune regulatory genes, T-cell associated genes, pattern recognition or innate host defense genes, immunglobin (Ig) or Ig-related genes, complement genes, antigen processing or presenting genes, and genes encoding endocrine hormones or their receptors. more...

Organism:

Arabidopsis thaliana; Bos taurus

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(Submitter supplied) Peumonia is the most common cause of death due to infectious diseases in the western hemisphere. The molecular events associated with pulmonary infections caused by Streptococcus pneumoniae and Influenza A virus are incompletely understood. Pathophysiological and protective processes are initiated by immune receptors specifically recognizing pathogenic structures serving to elicit a qualitatively and quantitatively adequate immune response. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2165

Platform:

GPL1868

7 Samples

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Analysis of female C57BL/6 lungs at various time points after influenza A virus or Streptococcus pneumoniae infection. Secondary bacterial infection during or after influenza recovery is common cause of pneumonia (PN). Results provide insight into molecular pathogenesis of severe infectious PN.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 2 infection, 5 time sets

Platform:

GPL1868

Series:

GSE5289

7 Samples

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(Submitter supplied) Sex Specific Transciption in Mouse Hypothalamus, Liver, Kidney, Ovary and Testis. For each somatic tissue there are 3 biological samples from different pools comprised of 10 animals for each sex each with a technical replicate. For each of the reproductive tissues there are 3 biological samples from different pools comprised of 10 animals with a technical replicate for each. Keywords = Mouse sex-specific transcription, gonad specific gene expression Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS565

Platform:

GPL339

48 Samples

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(Submitter supplied) Sex Specific Transciption in Human Hypothalamus between 7 male biological samples (2 technical replicates of each) and 5 female biological samples (2 technical replicates of 4 of these). Keywords = human hypothalamus, sex-specific transcription Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS564

Platform:

GPL96

23 Samples

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Analysis of sex specific transcription in somatic and reproductive tissues. Hypothalamus, liver, kidney, ovary, and testis tissues pooled from 10 different animals examined.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 gender, 5 tissue sets

Platform:

GPL339

Series:

GSE1148

48 Samples

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Examination of sex specific transcription in hypothalamus using postmortem samples from individuals averaging 70 years of age.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 gender sets

Platform:

GPL96

Series:

GSE1147

23 Samples

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(Submitter supplied) Gene expression is a complex quantitative trait partially regulated by genetic variation in DNA sequence. Population differences in gene expression could contribute to some of the observed differences in susceptibility to common diseases and responses to drug treatments. We characterize gene expression in the full set of HapMap lymphoblastoid cell lines derived from individuals of European and African ancestry for 9,156 transcript clusters (gene-level) evaluated using the Affymetrix GeneChip® Human Exon 1.0 ST Array. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

176 Samples

Download data: CEL, TXT