GEO DataSets

Expression profiling of livers from inbred Kyotos and outbred Wistars fed a diet with 1% orotic acid to induce fatty liver disease. Profiles examined at various time points up to 14 days. Results used together with NMR spectroscopic analysis of the liver to identify perturbed metabolic pathways.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 2 strain, 4 time sets

Platform:

GPL85

Series:

GSE665

18 Samples

Download data

(Submitter supplied) A time course of orotic acid induced fatty liver disease. Kyoto and Wistar strain rats were exposed to orotic acid for days 1, 3 and 14. Controls are also included. Keywords = Wistar Keywords = Kyoto Keywords = orotic acid Keywords: time-course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS765

Platform:

GPL85

14 Samples

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(Submitter supplied) The project had 2 goals: 1) To evaluate the transcriptional response of 3 prototypical toxicants (Clofibrate, VPA, and DEHP) on rat lever. 2) To evaluate the impact pooling samples has on data analysis. Keywords = Clofibrate Keywords = Diethylhexyl phthalate Keywords = Phthalic acid bis(2-ethylhexyl ester) Keywords = Sodium Valproate Keywords = Valproic Acid Keywords = VPA Keywords = vehicle Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1451

Platform:

GPL85

94 Samples

Download data: CEL, CHP, EXP

Analysis of livers of Sprague-Dawley males at various time points up to 168 hours after treatment with clofibrate, diethylhexylphthalate, or valproic acid. Expression profiles from pooled and individual samples compared. Results provide insight into the impact of pooling on experimental analysis.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 agent, 2 protocol, 4 time sets

Platform:

GPL85

Series:

GSE2303

94 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) Rodents respond to chronic high fat diet in at least two ways: some of them may readily gain body weight and become obese (termed obesity-prone), and others may not (termed obesity-resistant). An integrated approach of transcript and metabolic profiling of obesity-prone and obesity-resistant rats has been conducted, showing significantly different transcript and metabolic profiles in the two phenotypes. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3677

Platform:

GPL4294

8 Samples

Download data: TXT

Analysis of liver from obesity-prone (OP) Wistar males with nonalcoholic fatty liver disease (NAFLD) induced by a 16 week, high-fat diet (HFD). Obesity-resistant (OR) males, fed an identical diet, were also examined. Results provide insight into molecular mechanisms underlying NAFLD pathogenesis.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log ratio, 2 disease state sets

Platform:

GPL4294

Series:

GSE11492

8 Samples

Download data: TXT

(Submitter supplied) Cardiac hypertrophy was induced by treadmill running. Sedentary animals served as controls. Gene expression was determined by Affymetrix RGU34A GeneChip's to identify genes with differential expression in an adaptive model of cardiac hypertrophy. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS654

Platform:

GPL85

12 Samples

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Analysis of heart left ventricles from animals subjected to 7 weeks treadmill exercise compared with sedentary controls. Provides insight into molecular mechanisms of left ventricular hypertrophy.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL85

Series:

GSE739

12 Samples

Download data

(Submitter supplied) Exposure to PFOA during gestation altered the expression of genes related to fatty acid catabolism in both the fetal liver and lung. In the fetal liver, the effects of PFOA were robust and also included genes associated with lipid transport, ketogenesis, glucose metabolism, lipoprotein metabolism, cholesterol biosynthesis, steroid metabolism, bile acid biosynthesis, phospholipid metabolism, retinol metabolism, proteosome activation, and inflammation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS3410 GDS3411

Platform:

GPL1261

59 Samples

Download data: CEL

Analysis of livers or lungs of fetuses dosed during gestation with up to 3 mg/(kg day) perfluorooctanoic acid (PFOA), an industrial chemical that induces growth deficits and mortality in murine neonates. Results provide insight into the molecular basis of PFOA-induced developmental toxicity.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 dose, 2 tissue sets

Platform:

GPL1261

Series:

GSE13044

29 Samples

Download data: CEL

Analysis of livers or lungs of fetuses dosed during gestation with up to 10 mg/(kg day) perfluorooctanoic acid (PFOA), an industrial chemical that induces growth deficits and mortality in murine neonates. Results provide insight into the molecular basis of PFOA-induced developmental toxicity.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 dose, 2 tissue sets

Platform:

GPL1261

Series:

GSE13044

30 Samples

Download data: CEL

(Submitter supplied) The effect of cafeteria (CAF) diet in PBMC gene expression was analyzed in two inbred rat strains the Wistar Kyoto(WKY) and Lewis (LEW) rat PBMCs were isolated following a CAF or standard diet and subjected to whole genome expression analysis

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6247

20 Samples

Download data: CEL

(Submitter supplied) To investigate the molecular mechanisms associated with initial dose-related events that are linked to the development of liver tumours: liver growth; cell proliferation; changes in histopathology such as hypertrophy

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

48 Samples

Download data: CEL, TXT