Notch1 promoter deletion effect on Ikaros-deficient model of T-cell acute lymphoblastic leukemia: thymic lymphoma - - GEO DataSets

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Notch1 promoter deletion effect on Ikaros-deficient model of T-cell acute lymphoblastic leukemia: thymic lymphoma

Analysis of thymic tumors from Ikaros-deficient (IkL/L) mice with a Notch promoter/exon1 deletion. The deletion of Notch1 promoter results in oncogenic activation of Notch1 and significantly accelerates leukemogenesis. Results provide insight into role of Notch activation in pathogenesis of T-ALL.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 age, 2 genotype/variation sets

Platform:: GPL1261
Series:: GSE23972
6 Samples

Download data: CEL

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Accession:: GDS4174

ID:: 4174

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