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Full record GDS4290

Small-molecule DOT1L inhibitor EPZ004777 effect on mixed lineage leukemia cells: time course

Temporal analysis of mixed lineage leukemia (MLL)-rearranged cell lines MV4-11 and MOLM-13 treated with EPZ004777, a potent inhibitor of DOT1L histone methyl transferase. EPZ004777 induces differentiation and apoptosis in MLL-rearranged cells. Results provide insight into role of DOT1L in MLL cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 cell line, 3 time sets
Platform:
GPL570
Series:
GSE29828
24 Samples
Download data: CEL

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