GEO DataSets

(Submitter supplied) Exposure to maternal diabetes during pregnancy alters transcriptional profiles in the developing embryo. The enrichment, within the set of de-regulated genes, of those encoding transcriptional regulatory molecules provides support for the hypothesis that maternal diabetes affects specific developmental programs. We compared E10.5 cntrol embryos to E10.5 embryos from diabetic pregnancies in the FVB mouse strain.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4590

Platform:

GPL1261

6 Samples

Download data: CEL

(Submitter supplied) Diabetic embryopathy can affect any developing organ system, although cardiovascular malformations, neural tube defects and caudal dysgenesis syndrome are the most prominent congenital malformations. We hypothesize that the metabolic imbalance occurring in diabetic pregnancy de-regulates tissue specific gene expression programs in the developing embryo. In order to identify genes whose expression is affected by maternal diabetes, we analyzed gene expression profiles of diabetes-exposed mouse embryos by using Affymetrix microarrays. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4028

Platform:

GPL339

7 Samples

Download data: CEL, CHP

Analysis of embryonic day 10.5 (E10.5) embryos collected from streptozotocin-induced diabetic FVB females. Maternal diabetes is a known risk factor for birth defects. Results provide insight into molecular mechanisms underlying developmental abnormalities of embryos of diabetic pregnancies.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL1261

Series:

GSE41095

6 Samples

Download data: CEL

Analysis of diabetes-exposed, E10.5 whole embryos. Diabetes was induced in FVB females (aged 7-9 wks) by streptozotocin. Maternal diabetes is a well-known risk factor for birth defects, such as neural tube defects. Results provide insight into the causative molecular mechanisms in developing embryo.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 disease state, 2 stress sets

Platform:

GPL339

Series:

GSE9675

7 Samples

Download data: CEL, CHP