GEO DataSet Links for PMC (Select 2808372) - GEO DataSets

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Items: 2

Select item 2000186321.

Knockdown of transactive response DNA-binding protein TDP-43 downregulates histone deacetylase 6

(Submitter supplied) TDP-43 is an RNA/DNA-binding protein implicated in transcriptional repression and mRNA processing. Inclusions of TDP-43 are hallmarks of frontotemporal dementias and amyotrophic lateral sclerosis. Besides aggregation of TDP-43, loss of nuclear localization is observed in disease. To identify relevant targets of TDP-43, we performed an expression profiling study. Thereby, histone deacetylase 6 (HDAC6) downregulation was discovered upon TDP-43 silencing on mRNA and protein level in human embryonic kidney HEK293E and neuronal SH-SY5Y cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3730
Platform:: GPL570
8 Samples

Download data: CEL

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Accession:: GSE18632

ID:: 200018632

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 37302.

Transactive response DNA-binding protein (TDP-43) knockdown effect on embryonic kidney cells

Analysis of HEK293E cells depleted of transactive response DNA-binding protein (TDP-43). Inclusions of TDP-43 are hallmarks of frontotemporal dementia and amyotrophic lateral sclerosis (ALS). Results provide insight into the molecular basis of TDP-43 misfunction in neurodegenerative diseases.