GEO DataSets

(Submitter supplied) The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) results in the condition called “ER stress” which induces the unfolded protein response (UPR) which is a complex cellular process that includes changes in expression of many genes. Failure to restore homeostasis in the ER is associated with human diseases. To identify the underlying changes in gene expression in response to ER stress, we induced ER stress in human B-cells and then measured gene expression at 10 time-points. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS4129 GDS4130

Platform:

GPL570

224 Samples

Download data: CEL

Analysis of immortalized B cells from MZ twin pairs (14 of European ancestry, 12 African American) treated in vitro with thapsigargin to induce ER stress. ER stress induces the unfolded protein response (UPR). Results provide insight into the molecular basis of the UPR response within twin pairs.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 2 genotype/variation, 2 individual, 26 other sets

Platform:

GPL570

Series:

GSE19519

104 Samples

Download data: CEL

Analysis of immortalized B cells from 60 unrelated individuals (grandparents in the HapMap CEPH-Utah pedigrees) treated in vitro with tunicamycin to induce ER stress. ER stress induces the unfolded protein response (UPR). Results provide insight into molecular mechanisms underlying UPR response.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 60 individual sets

Platform:

GPL570

Series:

GSE19519

120 Samples

Download data: CEL