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Conserved Function of lincRNAs in Vertebrate Embryonic Development Despite Rapid Sequence Evolution

(Submitter supplied) Thousands of large intervening non-coding RNAs (lincRNAs) have been identified in mammals. To better understand the evolution and functions of these enigmatic RNAs, we used chromatin marks, poly(A)-site mapping and RNA-Seq data, to identify more than 550 distinct lincRNAs in zebrafish. Although these shared many characteristics with mammalian lincRNAs, only 29 had detectable sequence similarity with putative mammalian orthologs, typically restricted to a single short region of high conservation. more...
Organism:
Danio rerio
Type:
Non-coding RNA profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9319
16 Samples
Download data: BAM, BED, BW
Series
Accession:
GSE32880
ID:
200032880

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