GEO DataSet Links for PMC (Select 3827783) - GEO DataSets

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Items: 2

Select item 2000378741.

Shifted Metabolic Bias in Livers of Mice Lacking Hepatocytic Thioredoxin Reductase-1 Protects Against Acetaminophen Toxicity

(Submitter supplied) Genetic disruption of thioredoxin reductase 1 protects against acetaminophen (APAP) toxicity. To determine the role of the thioredoxin system on xenobiotic metabolism we challeneged wildtype and txnrd1liver-null mice with acetaminophen.

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4928
Platform:: GPL8321
12 Samples

Download data: CEL

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Accession:: GSE37874

ID:: 200037874

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 49282.

Acetaminophen effect on thioredoxin reductase 1-null liver

Analysis of liver from hepatocyte-specific, thioredoxin reductase 1 (TrxR1)-null mutants treated with the pro-toxin acetaminophen. The Trx system impacts bioenergetics and drug metabolism. Results provide insight into the role of the Trx system in detoxifying certain xenobiotic challenges.