GEO DataSet Links for PMC (Select 3938152) - GEO DataSets

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Items: 2

Select item 2000490671.

Expression data from responders/nonresponders before/after receiving DLI for relapse of CML s/p BMT

(Submitter supplied) Increasing evidence across malignancies suggests that infiltrating T cells at the site of disease are crucial to tumor control. We hypothesized that marrow-infiltrating immune populations play a critical role in response to donor lymphocyte infusion (DLI), an established and potentially curative immune therapy whose precise mechanism remains unknown. We therefore analyzed marrow-infiltrating immune populations in 29 patients (22 responders, 7 nonresponders) with relapsed chronic myelogenous leukemia who received CD4+ DLI in the pre-tyrosine kinase inhibitor era. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4871
Platform:: GPL571
12 Samples

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Accession:: GSE49067

ID:: 200049067

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 48712.

Donor lymphocyte infusion effect on bone marrow-infiltrating CD3+ T cells of patients with relapsed chronic myelogenous leukemia

Analysis of marrow-infiltrating CD3+ T cells isolated from relapsed chronic myelogenous leukemia (CML) patients following donor lymphocyte infusion (DLI) therapy. Four patients were DLI-responsive, two were DLI-nonresponsive. Results provide mechanistic insights into DLI response in relapsed CML.